Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects

Christian Drapeau,1 Kathleen F Benson,2 Gitte S Jensen2 1Biomx Stemceuticals, Austin, TX 78765, USA; 2NIS Labs, Klamath Falls, OR 97601, USA Purpose: The aim of this study was to evaluate the effects of a proanthocyanidin-rich extract of sea buckthorn berry (SBB-PE) on the numbers of various types...

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Autores principales:	Drapeau C, Benson KF, Jensen GS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	CD31 CD34 CD90 CD309 endothelial stem cells mesenchymal stem cells. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/3cda17a09cb04b3396378227ced39b83
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spelling	oai:doaj.org-article:3cda17a09cb04b3396378227ced39b832021-12-02T04:28:38ZRapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects1178-1998https://doaj.org/article/3cda17a09cb04b3396378227ced39b832019-02-01T00:00:00Zhttps://www.dovepress.com/rapid-and-selective-mobilization-of-specific-stem-cell-types-after-con-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Christian Drapeau,1 Kathleen F Benson,2 Gitte S Jensen2 1Biomx Stemceuticals, Austin, TX 78765, USA; 2NIS Labs, Klamath Falls, OR 97601, USA Purpose: The aim of this study was to evaluate the effects of a proanthocyanidin-rich extract of sea buckthorn berry (SBB-PE) on the numbers of various types of adult stem cells in the blood circulation of healthy human subjects. Study design and methods: A randomized, double-blind, placebo-controlled, cross-over trial was conducted in 12 healthy subjects. Blood samples were taken immediately before and at 1 and 2 hours after consuming either placebo or 500 mg SBB-PE. Whole blood was used for immunophenotyping and flow cytometry to quantify the numbers of CD45dim CD34+ CD309+ and CD45dim CD34+ CD309- stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ mesenchymal stem cells. Results: Consumption of SBB-PE was associated with a rapid and highly selective mobilization of CD45dim CD34+ CD309- progenitor stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ lymphocytoid mesenchymal stem cells. In contrast, only minor effects were seen for CD45dim CD34+ CD309+ pluripotential stem cells. Conclusion: Consumption of SBB-PE resulted in selective mobilization of stem cell types involved in regenerative and reparative functions. These data may contribute to the understanding of the traditional uses of SBB for preventive health, regenerative health, and postponing the aging process. Keywords: CD31, CD34, CD90, CD309, endothelial stem cells, mesenchymal stem cellsDrapeau CBenson KFJensen GSDove Medical PressarticleCD31CD34CD90CD309endothelial stem cellsmesenchymal stem cells.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 253-263 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	CD31 CD34 CD90 CD309 endothelial stem cells mesenchymal stem cells. Geriatrics RC952-954.6
spellingShingle	CD31 CD34 CD90 CD309 endothelial stem cells mesenchymal stem cells. Geriatrics RC952-954.6 Drapeau C Benson KF Jensen GS Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects
description	Christian Drapeau,1 Kathleen F Benson,2 Gitte S Jensen2 1Biomx Stemceuticals, Austin, TX 78765, USA; 2NIS Labs, Klamath Falls, OR 97601, USA Purpose: The aim of this study was to evaluate the effects of a proanthocyanidin-rich extract of sea buckthorn berry (SBB-PE) on the numbers of various types of adult stem cells in the blood circulation of healthy human subjects. Study design and methods: A randomized, double-blind, placebo-controlled, cross-over trial was conducted in 12 healthy subjects. Blood samples were taken immediately before and at 1 and 2 hours after consuming either placebo or 500 mg SBB-PE. Whole blood was used for immunophenotyping and flow cytometry to quantify the numbers of CD45dim CD34+ CD309+ and CD45dim CD34+ CD309- stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ mesenchymal stem cells. Results: Consumption of SBB-PE was associated with a rapid and highly selective mobilization of CD45dim CD34+ CD309- progenitor stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ lymphocytoid mesenchymal stem cells. In contrast, only minor effects were seen for CD45dim CD34+ CD309+ pluripotential stem cells. Conclusion: Consumption of SBB-PE resulted in selective mobilization of stem cell types involved in regenerative and reparative functions. These data may contribute to the understanding of the traditional uses of SBB for preventive health, regenerative health, and postponing the aging process. Keywords: CD31, CD34, CD90, CD309, endothelial stem cells, mesenchymal stem cells
format	article
author	Drapeau C Benson KF Jensen GS
author_facet	Drapeau C Benson KF Jensen GS
author_sort	Drapeau C
title	Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects
title_short	Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects
title_full	Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects
title_fullStr	Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects
title_full_unstemmed	Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects
title_sort	rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (hippophae) in healthy human subjects
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3cda17a09cb04b3396378227ced39b83
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Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects

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