To nick or not to nick: comparison of I-SceI single- and double-strand break-induced recombination in yeast and human cells.

To nick or not to nick: comparison of I-SceI single- and double-strand break-induced recombination in yeast and human cells.

Genetic modification of a chromosomal locus to replace an existing dysfunctional allele with a corrected sequence can be accomplished through targeted gene correction using the cell's homologous recombination (HR) machinery. Gene targeting is stimulated by generation of a DNA double-strand brea...

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Autores principales: Samantha S Katz, Frederick S Gimble, Francesca Storici
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3ce394158ba24f668fcf0cb80d0a81d1
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