DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

AgRP neurons in the hypothalamic arcuate nucleus (ARH) are involved in regulating hunger and energy balance. Here the authors show that knockout of the DNA methyltransferase Dnmt3a in AgRP neurons of the ARH leads to a reduction in voluntary exercise along with numerous epigenetic and gene expressio...

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Autores principales:	Harry MacKay, C. Anthony Scott, Jack D. Duryea, Maria S. Baker, Eleonora Laritsky, Amanda E. Elson, Theodore Garland Jr., Marta L. Fiorotto, Rui Chen, Yumei Li, Cristian Coarfa, Richard B. Simerly, Robert A. Waterland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ce73e60fe8e45fe8361296ab5b90707
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spelling	oai:doaj.org-article:3ce73e60fe8e45fe8361296ab5b907072021-12-02T17:01:46ZDNA methylation in AgRP neurons regulates voluntary exercise behavior in mice10.1038/s41467-019-13339-32041-1723https://doaj.org/article/3ce73e60fe8e45fe8361296ab5b907072019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13339-3https://doaj.org/toc/2041-1723AgRP neurons in the hypothalamic arcuate nucleus (ARH) are involved in regulating hunger and energy balance. Here the authors show that knockout of the DNA methyltransferase Dnmt3a in AgRP neurons of the ARH leads to a reduction in voluntary exercise along with numerous epigenetic and gene expression changes in ARH neurons.Harry MacKayC. Anthony ScottJack D. DuryeaMaria S. BakerEleonora LaritskyAmanda E. ElsonTheodore Garland Jr.Marta L. FiorottoRui ChenYumei LiCristian CoarfaRichard B. SimerlyRobert A. WaterlandNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Harry MacKay C. Anthony Scott Jack D. Duryea Maria S. Baker Eleonora Laritsky Amanda E. Elson Theodore Garland Jr. Marta L. Fiorotto Rui Chen Yumei Li Cristian Coarfa Richard B. Simerly Robert A. Waterland DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice
description	AgRP neurons in the hypothalamic arcuate nucleus (ARH) are involved in regulating hunger and energy balance. Here the authors show that knockout of the DNA methyltransferase Dnmt3a in AgRP neurons of the ARH leads to a reduction in voluntary exercise along with numerous epigenetic and gene expression changes in ARH neurons.
format	article
author	Harry MacKay C. Anthony Scott Jack D. Duryea Maria S. Baker Eleonora Laritsky Amanda E. Elson Theodore Garland Jr. Marta L. Fiorotto Rui Chen Yumei Li Cristian Coarfa Richard B. Simerly Robert A. Waterland
author_facet	Harry MacKay C. Anthony Scott Jack D. Duryea Maria S. Baker Eleonora Laritsky Amanda E. Elson Theodore Garland Jr. Marta L. Fiorotto Rui Chen Yumei Li Cristian Coarfa Richard B. Simerly Robert A. Waterland
author_sort	Harry MacKay
title	DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice
title_short	DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice
title_full	DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice
title_fullStr	DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice
title_full_unstemmed	DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice
title_sort	dna methylation in agrp neurons regulates voluntary exercise behavior in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3ce73e60fe8e45fe8361296ab5b90707
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DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

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