$Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review$
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Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review

Abstract Background To review, analyze and characterize the pregnancy and lactation-related osteoporosis (PLO) with vertebral fractures based on the extraction data in the previous studies. Methods A comprehensive literature search of electronic databases including the PubMed, Embase and Web of Scie...

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Autores principales:	Ying Qian, Lei Wang, Lili Yu, Weimin Huang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pregnancy Lactation Osteoporosis Vertebral fractures Systematic review Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/3cee4b6f7f6e40afa04c83c470253d69
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spelling	oai:doaj.org-article:3cee4b6f7f6e40afa04c83c470253d692021-11-08T10:58:27ZPregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review10.1186/s12891-021-04776-71471-2474https://doaj.org/article/3cee4b6f7f6e40afa04c83c470253d692021-11-01T00:00:00Zhttps://doi.org/10.1186/s12891-021-04776-7https://doaj.org/toc/1471-2474Abstract Background To review, analyze and characterize the pregnancy and lactation-related osteoporosis (PLO) with vertebral fractures based on the extraction data in the previous studies. Methods A comprehensive literature search of electronic databases including the PubMed, Embase and Web of Science was conducted from January 1st,1990 to December 1st, 2020. The enrolled data were pooled to analyze the baseline characteristics, clinical features, risk factors and treatment options. Results A total of 65 articles with 338 cases were enrolled for data extraction. The enrolled cases aged from 19 to 47 years, with a mean value of 35.7 years old. The average body mass index (BMI) was 22.2 kg/m2 ranged from 16.0 to 39.0 kg/m2. Of the 173 cases, 149 cases with vertebral fractures occurred in the first pregnancy, 19 cases in the second pregnancy, four cases in the third pregnancy and one case in the fourth pregnancy. Up to 91.5% of the back pain occurred within the last 3 months of pregnancy and the first 3 months after delivery. The most involved vertebral levels were L2, L1 and T12 accounting for 32.6% of all the fractures. The average fracture numbers were 4.4 levels per patient. The lumbar Z-scores were mostly recorded with a mean value of − 3.2 ranged from − 7.8 to 0. Conclusions PLO with vertebral fractures is a rare clinical entity, which is more likely to occur in older and thinner pregnant women. Back pain is the clinical complaint and mostly occurs in the late pregnancy and early lactation periods. Most vertebral fractures appear in the first pregnancy but it can occur in any time of pregnancy. Thoracolumbar region is the mostly involved region. As compared with postmenopausal osteoporotic fractures, PLO usually has multiple levels fractures. Bisphosphonates are the most widely used treatment so far, however, many factors need to be taken into account to decide which drug to choose in PLO and further studies are necessary for clear recommendation in the future.Ying QianLei WangLili YuWeimin HuangBMCarticlePregnancyLactationOsteoporosisVertebral fracturesSystematic reviewDiseases of the musculoskeletal systemRC925-935ENBMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pregnancy Lactation Osteoporosis Vertebral fractures Systematic review Diseases of the musculoskeletal system RC925-935
spellingShingle	Pregnancy Lactation Osteoporosis Vertebral fractures Systematic review Diseases of the musculoskeletal system RC925-935 Ying Qian Lei Wang Lili Yu Weimin Huang Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review
description	Abstract Background To review, analyze and characterize the pregnancy and lactation-related osteoporosis (PLO) with vertebral fractures based on the extraction data in the previous studies. Methods A comprehensive literature search of electronic databases including the PubMed, Embase and Web of Science was conducted from January 1st,1990 to December 1st, 2020. The enrolled data were pooled to analyze the baseline characteristics, clinical features, risk factors and treatment options. Results A total of 65 articles with 338 cases were enrolled for data extraction. The enrolled cases aged from 19 to 47 years, with a mean value of 35.7 years old. The average body mass index (BMI) was 22.2 kg/m2 ranged from 16.0 to 39.0 kg/m2. Of the 173 cases, 149 cases with vertebral fractures occurred in the first pregnancy, 19 cases in the second pregnancy, four cases in the third pregnancy and one case in the fourth pregnancy. Up to 91.5% of the back pain occurred within the last 3 months of pregnancy and the first 3 months after delivery. The most involved vertebral levels were L2, L1 and T12 accounting for 32.6% of all the fractures. The average fracture numbers were 4.4 levels per patient. The lumbar Z-scores were mostly recorded with a mean value of − 3.2 ranged from − 7.8 to 0. Conclusions PLO with vertebral fractures is a rare clinical entity, which is more likely to occur in older and thinner pregnant women. Back pain is the clinical complaint and mostly occurs in the late pregnancy and early lactation periods. Most vertebral fractures appear in the first pregnancy but it can occur in any time of pregnancy. Thoracolumbar region is the mostly involved region. As compared with postmenopausal osteoporotic fractures, PLO usually has multiple levels fractures. Bisphosphonates are the most widely used treatment so far, however, many factors need to be taken into account to decide which drug to choose in PLO and further studies are necessary for clear recommendation in the future.
format	article
author	Ying Qian Lei Wang Lili Yu Weimin Huang
author_facet	Ying Qian Lei Wang Lili Yu Weimin Huang
author_sort	Ying Qian
title	Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review
title_short	Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review
title_full	Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review
title_fullStr	Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review
title_full_unstemmed	Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review
title_sort	pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review
publisher	BMC
publishDate	2021
url	https://doaj.org/article/3cee4b6f7f6e40afa04c83c470253d69
work_keys_str_mv	AT yingqian pregnancyandlactationassociatedosteoporosiswithvertebralfracturesasystematicreview AT leiwang pregnancyandlactationassociatedosteoporosiswithvertebralfracturesasystematicreview AT liliyu pregnancyandlactationassociatedosteoporosiswithvertebralfracturesasystematicreview AT weiminhuang pregnancyandlactationassociatedosteoporosiswithvertebralfracturesasystematicreview
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Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review

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