Diagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies

Aim. To study the significance of clinical and laboratory non-invasive indexes along with the insulin resistance index when carrying out diagnostic assessment of non-alcoholic fatty liver disease (NAFLD) during screening examinations. Materials and methods. The study involved 348 employees workin...

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Autores principales:	Aleksandr E. Nosov, Mariia T. Zenina, Olga Y. Gorbushina, Anastasiia S. Baidina, Elena M. Vlasova, Vadim B. Alekseev
Formato:	article
Lenguaje:	RU
Publicado:	"Consilium Medicum" Publishing house 2021
Materias:	non-alcoholic fatty liver disease ultrasound scanning of the liver insulin resistance steatosis indexes Medicine R
Acceso en línea:	https://doaj.org/article/3cee5aaa82a146e1aca7ea4069fc4b81
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spelling	oai:doaj.org-article:3cee5aaa82a146e1aca7ea4069fc4b812021-12-01T12:22:36ZDiagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies0040-36602309-534210.26442/00403660.2021.08.200973https://doaj.org/article/3cee5aaa82a146e1aca7ea4069fc4b812021-08-01T00:00:00Zhttps://ter-arkhiv.ru/0040-3660/article/viewFile/79422/60068https://doaj.org/toc/0040-3660https://doaj.org/toc/2309-5342Aim. To study the significance of clinical and laboratory non-invasive indexes along with the insulin resistance index when carrying out diagnostic assessment of non-alcoholic fatty liver disease (NAFLD) during screening examinations. Materials and methods. The study involved 348 employees working at oil-production enterprises. An ultrasound scanning of the liver was carried out to assess the criteria of NAFLD. The following indexes were calculated: fatty liver index (FLI), hepatic steatosis index (HSI), lipid accumulation products (LAP), and homeostasis model assessment of insulin resistance (HOMA1-IR). The prognostic significance of these indexes in relation to the probability of NAFLD diagnosis based on ultrasound data was studied using single-factor and multi-factor logistic regression models followed by ROC-analysis. Results. The FLI, HSI, and HOMA1-IR indexes in single-factor logistic regression models showed a high statistical significance when carrying out diagnostic assessment the NAFLD with good model calibration capability. The percentage of correct binary classification regards the presence/absence of NAFLD amounted to 82.4% for FLI, 79.7% for HSI, and 72.7% for HOMA1-IR (p0.001). According to the ROC-analysis, the area under the curve (AUC) by the NAFLD diagnostic assessment was 0.917 (95% CI 0.8890.945); 0.880 (95% CI 0.8460.915) and 0.849 (95% CI 0.7640.934), respectively. The multi-factor logistic regression model with the inclusion of FLI and HOMA1-IR 72.7% enabled us to achieve the correct binary classification in terms of NAFLD in 84.2% of cases. When it comes to the ROC-analysis, considering the probabilities predicted in the multi-factor logistic model as the test variable and NAFLD in ultrasound examination as the state variable, it was possible to set the value of AUC 0.933 (95% CI 0.8820.985). Conclusion. The studied clinical and laboratory indexes (FLI, HSI, HOMA1-IR) have a high diagnostic significance regarding NAFLD diagnosed using ultrasonographic criteria. The application of the proposed two-factor logistics model makes it possible to predict the presence of NAFLD when examining a large number of patients, without involving additional ultrasound diagnostics specialists in order to use medical resources rationally.Aleksandr E. NosovMariia T. ZeninaOlga Y. GorbushinaAnastasiia S. BaidinaElena M. VlasovaVadim B. Alekseev"Consilium Medicum" Publishing housearticlenon-alcoholic fatty liver diseaseultrasound scanning of the liverinsulin resistancesteatosis indexesMedicineRRUТерапевтический архив, Vol 93, Iss 8, Pp 883-889 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	non-alcoholic fatty liver disease ultrasound scanning of the liver insulin resistance steatosis indexes Medicine R
spellingShingle	non-alcoholic fatty liver disease ultrasound scanning of the liver insulin resistance steatosis indexes Medicine R Aleksandr E. Nosov Mariia T. Zenina Olga Y. Gorbushina Anastasiia S. Baidina Elena M. Vlasova Vadim B. Alekseev Diagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies
description	Aim. To study the significance of clinical and laboratory non-invasive indexes along with the insulin resistance index when carrying out diagnostic assessment of non-alcoholic fatty liver disease (NAFLD) during screening examinations. Materials and methods. The study involved 348 employees working at oil-production enterprises. An ultrasound scanning of the liver was carried out to assess the criteria of NAFLD. The following indexes were calculated: fatty liver index (FLI), hepatic steatosis index (HSI), lipid accumulation products (LAP), and homeostasis model assessment of insulin resistance (HOMA1-IR). The prognostic significance of these indexes in relation to the probability of NAFLD diagnosis based on ultrasound data was studied using single-factor and multi-factor logistic regression models followed by ROC-analysis. Results. The FLI, HSI, and HOMA1-IR indexes in single-factor logistic regression models showed a high statistical significance when carrying out diagnostic assessment the NAFLD with good model calibration capability. The percentage of correct binary classification regards the presence/absence of NAFLD amounted to 82.4% for FLI, 79.7% for HSI, and 72.7% for HOMA1-IR (p0.001). According to the ROC-analysis, the area under the curve (AUC) by the NAFLD diagnostic assessment was 0.917 (95% CI 0.8890.945); 0.880 (95% CI 0.8460.915) and 0.849 (95% CI 0.7640.934), respectively. The multi-factor logistic regression model with the inclusion of FLI and HOMA1-IR 72.7% enabled us to achieve the correct binary classification in terms of NAFLD in 84.2% of cases. When it comes to the ROC-analysis, considering the probabilities predicted in the multi-factor logistic model as the test variable and NAFLD in ultrasound examination as the state variable, it was possible to set the value of AUC 0.933 (95% CI 0.8820.985). Conclusion. The studied clinical and laboratory indexes (FLI, HSI, HOMA1-IR) have a high diagnostic significance regarding NAFLD diagnosed using ultrasonographic criteria. The application of the proposed two-factor logistics model makes it possible to predict the presence of NAFLD when examining a large number of patients, without involving additional ultrasound diagnostics specialists in order to use medical resources rationally.
format	article
author	Aleksandr E. Nosov Mariia T. Zenina Olga Y. Gorbushina Anastasiia S. Baidina Elena M. Vlasova Vadim B. Alekseev
author_facet	Aleksandr E. Nosov Mariia T. Zenina Olga Y. Gorbushina Anastasiia S. Baidina Elena M. Vlasova Vadim B. Alekseev
author_sort	Aleksandr E. Nosov
title	Diagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies
title_short	Diagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies
title_full	Diagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies
title_fullStr	Diagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies
title_full_unstemmed	Diagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies
title_sort	diagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies
publisher	"Consilium Medicum" Publishing house
publishDate	2021
url	https://doaj.org/article/3cee5aaa82a146e1aca7ea4069fc4b81
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Diagnostic significance of clinical and laboratory indices in predicting non-alcoholic fatty liver disease during screening studies

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