Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis.

The expression of selected microRNAs (miRNAs) known to be involved in the regulation of immune responses was analyzed in 74 patients with relapsing remitting multiple sclerosis (RRMS) and 32 healthy controls. Four miRNAs (miR-326, miR-155, miR-146a, miR-142-3p) were aberrantly expressed in periphera...

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Autores principales:	Anne Waschbisch, Monika Atiya, Ralf A Linker, Sergej Potapov, Stefan Schwab, Tobias Derfuss
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3cf81de8c2f249a5a29853a0a653fa2f
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spelling	oai:doaj.org-article:3cf81de8c2f249a5a29853a0a653fa2f2021-11-04T06:08:24ZGlatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis.1932-620310.1371/journal.pone.0024604https://doaj.org/article/3cf81de8c2f249a5a29853a0a653fa2f2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21949733/?tool=EBIhttps://doaj.org/toc/1932-6203The expression of selected microRNAs (miRNAs) known to be involved in the regulation of immune responses was analyzed in 74 patients with relapsing remitting multiple sclerosis (RRMS) and 32 healthy controls. Four miRNAs (miR-326, miR-155, miR-146a, miR-142-3p) were aberrantly expressed in peripheral blood mononuclear cells from RRMS patients compared to controls. Although expression of these selected miRNAs did not differ between treatment-naïve (n = 36) and interferon-beta treated RRMS patients (n = 18), expression of miR-146a and miR-142-3p was significantly lower in glatiramer acetate (GA) treated RRMS patients (n = 20) suggesting that GA, at least in part, restores the expression of deregulated miRNAs in MS.Anne WaschbischMonika AtiyaRalf A LinkerSergej PotapovStefan SchwabTobias DerfussPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24604 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne Waschbisch Monika Atiya Ralf A Linker Sergej Potapov Stefan Schwab Tobias Derfuss Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis.
description	The expression of selected microRNAs (miRNAs) known to be involved in the regulation of immune responses was analyzed in 74 patients with relapsing remitting multiple sclerosis (RRMS) and 32 healthy controls. Four miRNAs (miR-326, miR-155, miR-146a, miR-142-3p) were aberrantly expressed in peripheral blood mononuclear cells from RRMS patients compared to controls. Although expression of these selected miRNAs did not differ between treatment-naïve (n = 36) and interferon-beta treated RRMS patients (n = 18), expression of miR-146a and miR-142-3p was significantly lower in glatiramer acetate (GA) treated RRMS patients (n = 20) suggesting that GA, at least in part, restores the expression of deregulated miRNAs in MS.
format	article
author	Anne Waschbisch Monika Atiya Ralf A Linker Sergej Potapov Stefan Schwab Tobias Derfuss
author_facet	Anne Waschbisch Monika Atiya Ralf A Linker Sergej Potapov Stefan Schwab Tobias Derfuss
author_sort	Anne Waschbisch
title	Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis.
title_short	Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis.
title_full	Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis.
title_fullStr	Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis.
title_full_unstemmed	Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis.
title_sort	glatiramer acetate treatment normalizes deregulated microrna expression in relapsing remitting multiple sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/3cf81de8c2f249a5a29853a0a653fa2f
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Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis.

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