Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions

Abstract Chondroitin sulfate (CS) has been widely used for medical and nutraceutical purposes due to its roles in maintaining tissue structural integrity. We investigated if CS disaccharides may act as a bioactive compound and modulate gut microbial composition in mice. Our data show that CS disacch...

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Autores principales:	Fang Liu, Na Zhang, Zhaojie Li, Xiong Wang, Hongjie Shi, Changhu Xue, Robert W. Li, Qingjuan Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3cf9670c5de346b4b197098e82d3451e
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spelling	oai:doaj.org-article:3cf9670c5de346b4b197098e82d3451e2021-12-02T15:05:10ZChondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions10.1038/s41598-017-05860-62045-2322https://doaj.org/article/3cf9670c5de346b4b197098e82d3451e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05860-6https://doaj.org/toc/2045-2322Abstract Chondroitin sulfate (CS) has been widely used for medical and nutraceutical purposes due to its roles in maintaining tissue structural integrity. We investigated if CS disaccharides may act as a bioactive compound and modulate gut microbial composition in mice. Our data show that CS disaccharides supplementation for 16 days significantly reduced blood LPS in the mice experiencing exhaustive exercise stress. CS disaccharides partially restored total fecal short-chain fatty acids from the level significantly repressed in mice under the stress. Our findings demonstrated that CS was likely butyrogenic and resulted in a significant increase in fecal butyrate concentration. CS disaccharides had a profound impact on gut microbial composition, affecting the abundance of 13.6% and 7.3% Operational Taxonomic Units in fecal microbial communities in healthy and stressed mice, respectively. CS disaccharides reduced the prevalence of inflammatory Proteobacteria. Together, our findings demonstrated that CS may ameliorate stress-induced intestinal inflammation. Furthermore, CS significantly increased intestinal Bacteroides acidifaciens population, indirectly exerting its immunomodulatory effect on the intestine. CS disaccharides had a significant impact on a broad range of biological pathways under stressed condition, such as ABC transporters, two-component systems, and carbohydrate metabolism. Our results will facilitate the development of CS as a bioactive nutraceutical.Fang LiuNa ZhangZhaojie LiXiong WangHongjie ShiChanghu XueRobert W. LiQingjuan TangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fang Liu Na Zhang Zhaojie Li Xiong Wang Hongjie Shi Changhu Xue Robert W. Li Qingjuan Tang Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions
description	Abstract Chondroitin sulfate (CS) has been widely used for medical and nutraceutical purposes due to its roles in maintaining tissue structural integrity. We investigated if CS disaccharides may act as a bioactive compound and modulate gut microbial composition in mice. Our data show that CS disaccharides supplementation for 16 days significantly reduced blood LPS in the mice experiencing exhaustive exercise stress. CS disaccharides partially restored total fecal short-chain fatty acids from the level significantly repressed in mice under the stress. Our findings demonstrated that CS was likely butyrogenic and resulted in a significant increase in fecal butyrate concentration. CS disaccharides had a profound impact on gut microbial composition, affecting the abundance of 13.6% and 7.3% Operational Taxonomic Units in fecal microbial communities in healthy and stressed mice, respectively. CS disaccharides reduced the prevalence of inflammatory Proteobacteria. Together, our findings demonstrated that CS may ameliorate stress-induced intestinal inflammation. Furthermore, CS significantly increased intestinal Bacteroides acidifaciens population, indirectly exerting its immunomodulatory effect on the intestine. CS disaccharides had a significant impact on a broad range of biological pathways under stressed condition, such as ABC transporters, two-component systems, and carbohydrate metabolism. Our results will facilitate the development of CS as a bioactive nutraceutical.
format	article
author	Fang Liu Na Zhang Zhaojie Li Xiong Wang Hongjie Shi Changhu Xue Robert W. Li Qingjuan Tang
author_facet	Fang Liu Na Zhang Zhaojie Li Xiong Wang Hongjie Shi Changhu Xue Robert W. Li Qingjuan Tang
author_sort	Fang Liu
title	Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions
title_short	Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions
title_full	Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions
title_fullStr	Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions
title_full_unstemmed	Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions
title_sort	chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3cf9670c5de346b4b197098e82d3451e
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Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions

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