Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection

MANF is a secreted ER stress-inducible protein that protects neurons, pancreatic β cells and cardiomyocytes from cell death under oxidative stress, hypoxic or ischemic conditions. Here the authors show that MANF confers cytoprotection through direct binding to sulfatide followed by cellular uptake i...

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Autores principales:	Meirong Bai, Roman Vozdek, Aleš Hnízda, Chenxiao Jiang, Bingying Wang, Ladislav Kuchar, Tiejun Li, Yuefan Zhang, Chase Wood, Liang Feng, Yongjun Dang, Dengke K. Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3cf989f2d1324ba5867f71eac528a672
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id	oai:doaj.org-article:3cf989f2d1324ba5867f71eac528a672
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spelling	oai:doaj.org-article:3cf989f2d1324ba5867f71eac528a6722021-12-02T16:49:18ZConserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection10.1038/s41467-018-03355-02041-1723https://doaj.org/article/3cf989f2d1324ba5867f71eac528a6722018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03355-0https://doaj.org/toc/2041-1723MANF is a secreted ER stress-inducible protein that protects neurons, pancreatic β cells and cardiomyocytes from cell death under oxidative stress, hypoxic or ischemic conditions. Here the authors show that MANF confers cytoprotection through direct binding to sulfatide followed by cellular uptake in both C. elegans and mammalian cells.Meirong BaiRoman VozdekAleš HnízdaChenxiao JiangBingying WangLadislav KucharTiejun LiYuefan ZhangChase WoodLiang FengYongjun DangDengke K. MaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meirong Bai Roman Vozdek Aleš Hnízda Chenxiao Jiang Bingying Wang Ladislav Kuchar Tiejun Li Yuefan Zhang Chase Wood Liang Feng Yongjun Dang Dengke K. Ma Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection
description	MANF is a secreted ER stress-inducible protein that protects neurons, pancreatic β cells and cardiomyocytes from cell death under oxidative stress, hypoxic or ischemic conditions. Here the authors show that MANF confers cytoprotection through direct binding to sulfatide followed by cellular uptake in both C. elegans and mammalian cells.
format	article
author	Meirong Bai Roman Vozdek Aleš Hnízda Chenxiao Jiang Bingying Wang Ladislav Kuchar Tiejun Li Yuefan Zhang Chase Wood Liang Feng Yongjun Dang Dengke K. Ma
author_facet	Meirong Bai Roman Vozdek Aleš Hnízda Chenxiao Jiang Bingying Wang Ladislav Kuchar Tiejun Li Yuefan Zhang Chase Wood Liang Feng Yongjun Dang Dengke K. Ma
author_sort	Meirong Bai
title	Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection
title_short	Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection
title_full	Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection
title_fullStr	Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection
title_full_unstemmed	Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection
title_sort	conserved roles of c. elegans and human manfs in sulfatide binding and cytoprotection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3cf989f2d1324ba5867f71eac528a672
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Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection

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