Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation

Nucleases are regulated during the cell cycle to control for crossover formation and maintain genome integrity. Here the authors reveal that the yeast Holliday junction resolvase Yen is a sumoylation target and it is regulated by the ubiquitin ligases Slx5/Slx8 during crossover formation.

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Autores principales:	Ibtissam Talhaoui, Manuel Bernal, Janet R. Mullen, Hugo Dorison, Benoit Palancade, Steven J. Brill, Gerard Mazón
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3cfa65190830498d99dea1560cd9177b
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spelling	oai:doaj.org-article:3cfa65190830498d99dea1560cd9177b2021-12-02T16:49:35ZSlx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation10.1038/s41467-018-07364-x2041-1723https://doaj.org/article/3cfa65190830498d99dea1560cd9177b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07364-xhttps://doaj.org/toc/2041-1723Nucleases are regulated during the cell cycle to control for crossover formation and maintain genome integrity. Here the authors reveal that the yeast Holliday junction resolvase Yen is a sumoylation target and it is regulated by the ubiquitin ligases Slx5/Slx8 during crossover formation.Ibtissam TalhaouiManuel BernalJanet R. MullenHugo DorisonBenoit PalancadeSteven J. BrillGerard MazónNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ibtissam Talhaoui Manuel Bernal Janet R. Mullen Hugo Dorison Benoit Palancade Steven J. Brill Gerard Mazón Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
description	Nucleases are regulated during the cell cycle to control for crossover formation and maintain genome integrity. Here the authors reveal that the yeast Holliday junction resolvase Yen is a sumoylation target and it is regulated by the ubiquitin ligases Slx5/Slx8 during crossover formation.
format	article
author	Ibtissam Talhaoui Manuel Bernal Janet R. Mullen Hugo Dorison Benoit Palancade Steven J. Brill Gerard Mazón
author_facet	Ibtissam Talhaoui Manuel Bernal Janet R. Mullen Hugo Dorison Benoit Palancade Steven J. Brill Gerard Mazón
author_sort	Ibtissam Talhaoui
title	Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
title_short	Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
title_full	Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
title_fullStr	Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
title_full_unstemmed	Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
title_sort	slx5-slx8 ubiquitin ligase targets active pools of the yen1 nuclease to limit crossover formation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3cfa65190830498d99dea1560cd9177b
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Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation

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