Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans

Oksana Gorobets,1,2 Svitlana Gorobets,1 Marceli Koralewski3 1National Technical University of Ukraine (Igor Sikorsky Kyiv Polytechnic Institute), 2Institute of Magnetism, National Academy of Sciences, Kiev, Ukraine; 3Faculty of Physics, Adam Mickiewicz University, Poznan, Poland Abstract: The disc...

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Autores principales:	Gorobets O, Gorobets S, Koralewski M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	biogenic magnetic nanoparticles biomineralization ferritin magnetoferritin genetic control of biomineralization neurodegenerative disorders cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3cfa8c74bb8f4ce6b0501d81a090d71d
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spelling	oai:doaj.org-article:3cfa8c74bb8f4ce6b0501d81a090d71d2021-12-02T02:52:21ZPhysiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans1178-2013https://doaj.org/article/3cfa8c74bb8f4ce6b0501d81a090d71d2017-06-01T00:00:00Zhttps://www.dovepress.com/physiological-origin-of-biogenic-magnetic-nanoparticles-in-health-and--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Oksana Gorobets,1,2 Svitlana Gorobets,1 Marceli Koralewski3 1National Technical University of Ukraine (Igor Sikorsky Kyiv Polytechnic Institute), 2Institute of Magnetism, National Academy of Sciences, Kiev, Ukraine; 3Faculty of Physics, Adam Mickiewicz University, Poznan, Poland Abstract: The discovery of biogenic magnetic nanoparticles (BMNPs) in the human brain gives a strong impulse to study and understand their origin. Although knowledge of the subject is increasing continuously, much remains to be done for further development to help our society fight a number of pathologies related to BMNPs. This review provides an insight into the puzzle of the physiological origin of BMNPs in organisms of all three domains of life: prokaryotes, archaea, and eukaryotes, including humans. Predictions based on comparative genomic studies are presented along with experimental data obtained by physical methods. State-of-the-art understanding of the genetic control of biomineralization of BMNPs and their properties are discussed in detail. We present data on the differences in BMNP levels in health and disease (cancer, neurodegenerative disorders, and atherosclerosis), and discuss the existing hypotheses on the biological functions of BMNPs, with special attention paid to the role of the ferritin core and apoferritin. Keywords: biogenic magnetic nanoparticles, biomineralization, ferritin, magnetoferritin, genetic control, neurodegenerative disorders, cancerGorobets OGorobets SKoralewski MDove Medical Pressarticlebiogenic magnetic nanoparticlesbiomineralizationferritinmagnetoferritingenetic control of biomineralizationneurodegenerative disorderscancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4371-4395 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	biogenic magnetic nanoparticles biomineralization ferritin magnetoferritin genetic control of biomineralization neurodegenerative disorders cancer Medicine (General) R5-920
spellingShingle	biogenic magnetic nanoparticles biomineralization ferritin magnetoferritin genetic control of biomineralization neurodegenerative disorders cancer Medicine (General) R5-920 Gorobets O Gorobets S Koralewski M Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans
description	Oksana Gorobets,1,2 Svitlana Gorobets,1 Marceli Koralewski3 1National Technical University of Ukraine (Igor Sikorsky Kyiv Polytechnic Institute), 2Institute of Magnetism, National Academy of Sciences, Kiev, Ukraine; 3Faculty of Physics, Adam Mickiewicz University, Poznan, Poland Abstract: The discovery of biogenic magnetic nanoparticles (BMNPs) in the human brain gives a strong impulse to study and understand their origin. Although knowledge of the subject is increasing continuously, much remains to be done for further development to help our society fight a number of pathologies related to BMNPs. This review provides an insight into the puzzle of the physiological origin of BMNPs in organisms of all three domains of life: prokaryotes, archaea, and eukaryotes, including humans. Predictions based on comparative genomic studies are presented along with experimental data obtained by physical methods. State-of-the-art understanding of the genetic control of biomineralization of BMNPs and their properties are discussed in detail. We present data on the differences in BMNP levels in health and disease (cancer, neurodegenerative disorders, and atherosclerosis), and discuss the existing hypotheses on the biological functions of BMNPs, with special attention paid to the role of the ferritin core and apoferritin. Keywords: biogenic magnetic nanoparticles, biomineralization, ferritin, magnetoferritin, genetic control, neurodegenerative disorders, cancer
format	article
author	Gorobets O Gorobets S Koralewski M
author_facet	Gorobets O Gorobets S Koralewski M
author_sort	Gorobets O
title	Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans
title_short	Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans
title_full	Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans
title_fullStr	Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans
title_full_unstemmed	Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans
title_sort	physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/3cfa8c74bb8f4ce6b0501d81a090d71d
work_keys_str_mv	AT gorobetso physiologicaloriginofbiogenicmagneticnanoparticlesinhealthanddiseasefrombacteriatohumans AT gorobetss physiologicaloriginofbiogenicmagneticnanoparticlesinhealthanddiseasefrombacteriatohumans AT koralewskim physiologicaloriginofbiogenicmagneticnanoparticlesinhealthanddiseasefrombacteriatohumans
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Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans

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