Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus

Abstract Herein we describe an association between activation of inflammatory pathways following transient hypoxia and the appearance of the multidrug resistant bacteria Staphylococcus simulans in the fetal brain. Reduction of maternal arterial oxygen tension by 50% over 30 min resulted in a subseiu...

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Autores principales:	Miguel A. Zarate, Michelle D. Rodriguez, Eileen I. Chang, Jordan T. Russell, Thomas J. Arndt, Elaine M. Richards, Beronica A. Ocasio, Eva Aranda, Elizabeth M. Gordon, Kevin Yu, Josef Neu, Maureen Keller-Wood, Eric W. Triplett, Charles E. Wood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3cfd4a433f0f4938841b31318171a1dc
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spelling	oai:doaj.org-article:3cfd4a433f0f4938841b31318171a1dc2021-12-02T16:07:01ZPost-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus10.1038/s41598-017-06789-62045-2322https://doaj.org/article/3cfd4a433f0f4938841b31318171a1dc2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06789-6https://doaj.org/toc/2045-2322Abstract Herein we describe an association between activation of inflammatory pathways following transient hypoxia and the appearance of the multidrug resistant bacteria Staphylococcus simulans in the fetal brain. Reduction of maternal arterial oxygen tension by 50% over 30 min resulted in a subseiuent significant over-expression of genes associated with immune responses 24 h later in the fetal brain. The activated genes were consistent with stimulation by bacterial lipopolysaccharide; an influx of macrophages and appearance of live bacteria were found in these fetal brains. S. simulans was the predominant bacterial species in fetal brain after hypoxia, but was found in placenta of all animals. Strains of S. simulans from the placenta and fetal brain were equally highly resistant to multiple antibiotics including methicillin and had identical genome sequences. These results suggest that bacteria from the placenta invade the fetal brain after maternal hypoxia.Miguel A. ZarateMichelle D. RodriguezEileen I. ChangJordan T. RussellThomas J. ArndtElaine M. RichardsBeronica A. OcasioEva ArandaElizabeth M. GordonKevin YuJosef NeuMaureen Keller-WoodEric W. TriplettCharles E. WoodNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Miguel A. Zarate Michelle D. Rodriguez Eileen I. Chang Jordan T. Russell Thomas J. Arndt Elaine M. Richards Beronica A. Ocasio Eva Aranda Elizabeth M. Gordon Kevin Yu Josef Neu Maureen Keller-Wood Eric W. Triplett Charles E. Wood Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus
description	Abstract Herein we describe an association between activation of inflammatory pathways following transient hypoxia and the appearance of the multidrug resistant bacteria Staphylococcus simulans in the fetal brain. Reduction of maternal arterial oxygen tension by 50% over 30 min resulted in a subseiuent significant over-expression of genes associated with immune responses 24 h later in the fetal brain. The activated genes were consistent with stimulation by bacterial lipopolysaccharide; an influx of macrophages and appearance of live bacteria were found in these fetal brains. S. simulans was the predominant bacterial species in fetal brain after hypoxia, but was found in placenta of all animals. Strains of S. simulans from the placenta and fetal brain were equally highly resistant to multiple antibiotics including methicillin and had identical genome sequences. These results suggest that bacteria from the placenta invade the fetal brain after maternal hypoxia.
format	article
author	Miguel A. Zarate Michelle D. Rodriguez Eileen I. Chang Jordan T. Russell Thomas J. Arndt Elaine M. Richards Beronica A. Ocasio Eva Aranda Elizabeth M. Gordon Kevin Yu Josef Neu Maureen Keller-Wood Eric W. Triplett Charles E. Wood
author_facet	Miguel A. Zarate Michelle D. Rodriguez Eileen I. Chang Jordan T. Russell Thomas J. Arndt Elaine M. Richards Beronica A. Ocasio Eva Aranda Elizabeth M. Gordon Kevin Yu Josef Neu Maureen Keller-Wood Eric W. Triplett Charles E. Wood
author_sort	Miguel A. Zarate
title	Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus
title_short	Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus
title_full	Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus
title_fullStr	Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus
title_full_unstemmed	Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus
title_sort	post-hypoxia invasion of the fetal brain by multidrug resistant staphylococcus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3cfd4a433f0f4938841b31318171a1dc
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Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus

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