Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats

Saleh Al-Quraishy,1 Mohamed A Dkhil,1,2 Ahmed Esmat Abdel Moneim2 1Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt Abstract: The study was designed to investigate the a...

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Autores principales:	Al-Quraishy S, Dkhil MA, Abdel Moneim AE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3cff35d86b274626b6a273a82d8d3465
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spelling	oai:doaj.org-article:3cff35d86b274626b6a273a82d8d34652021-12-02T00:43:22ZAnti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats1178-2013https://doaj.org/article/3cff35d86b274626b6a273a82d8d34652015-10-01T00:00:00Zhttps://www.dovepress.com/anti-hyperglycemic-activity-of-selenium-nanoparticles-in-streptozotoci-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Saleh Al-Quraishy,1 Mohamed A Dkhil,1,2 Ahmed Esmat Abdel Moneim2 1Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt Abstract: The study was designed to investigate the anti-hyperglycemic activity of selenium nanoparticles (SeNPs) in streptozotocin-induced diabetic rats. Fifty-five mg/kg of streptozotocin was injected in rats to induce diabetes. Animals either treated with SeNPs alone or with insulin (6 U/kg) showed significantly decreased fasting blood glucose levels after 28 days of treatment. The serum insulin concentration in untreated diabetic animals was also enhanced by SeNPs. The results demonstrated that SeNPs could significantly decrease hepatic and renal function markers, total lipid, total cholesterol, triglyceride and low-density lipoprotein cholesterol levels, and glucose-6-phosphatase activity. At the same time, SeNPs increased malic enzyme, hexokinase and glucose-6-phosphate dehydrogenase activity, liver and kidney glycogen contents, and high-density lipoprotein cholesterol levels. In addition, SeNPs were able to prevent the histological injury in the hepatic and renal tissues of rats. However, insulin injection also exhibited a significant improvement in diabetic animals after 28 days of treatment. This study suggests that SeNPs can alleviate hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats, possibly by eliciting insulin-mimetic activity. Keywords: diabetes, selenium, liver, kidney, toxicityAl-Quraishy SDkhil MAAbdel Moneim AEDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 6741-6756 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Al-Quraishy S Dkhil MA Abdel Moneim AE Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats
description	Saleh Al-Quraishy,1 Mohamed A Dkhil,1,2 Ahmed Esmat Abdel Moneim2 1Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt Abstract: The study was designed to investigate the anti-hyperglycemic activity of selenium nanoparticles (SeNPs) in streptozotocin-induced diabetic rats. Fifty-five mg/kg of streptozotocin was injected in rats to induce diabetes. Animals either treated with SeNPs alone or with insulin (6 U/kg) showed significantly decreased fasting blood glucose levels after 28 days of treatment. The serum insulin concentration in untreated diabetic animals was also enhanced by SeNPs. The results demonstrated that SeNPs could significantly decrease hepatic and renal function markers, total lipid, total cholesterol, triglyceride and low-density lipoprotein cholesterol levels, and glucose-6-phosphatase activity. At the same time, SeNPs increased malic enzyme, hexokinase and glucose-6-phosphate dehydrogenase activity, liver and kidney glycogen contents, and high-density lipoprotein cholesterol levels. In addition, SeNPs were able to prevent the histological injury in the hepatic and renal tissues of rats. However, insulin injection also exhibited a significant improvement in diabetic animals after 28 days of treatment. This study suggests that SeNPs can alleviate hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats, possibly by eliciting insulin-mimetic activity. Keywords: diabetes, selenium, liver, kidney, toxicity
format	article
author	Al-Quraishy S Dkhil MA Abdel Moneim AE
author_facet	Al-Quraishy S Dkhil MA Abdel Moneim AE
author_sort	Al-Quraishy S
title	Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats
title_short	Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats
title_full	Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats
title_fullStr	Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats
title_full_unstemmed	Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats
title_sort	anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/3cff35d86b274626b6a273a82d8d3465
work_keys_str_mv	AT alquraishys antihyperglycemicactivityofseleniumnanoparticlesinstreptozotocininduceddiabeticrats AT dkhilma antihyperglycemicactivityofseleniumnanoparticlesinstreptozotocininduceddiabeticrats AT abdelmoneimae antihyperglycemicactivityofseleniumnanoparticlesinstreptozotocininduceddiabeticrats
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Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats

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