Risk factors for progression to blindness in high tension primary open angle glaucoma: Comparison of blind and nonblind subjects

Karanjit S Kooner1, Mohannad AlBdoor1, Byung J Cho3, Beverley Adams-Huet21Department of Ophthalmology, 2Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA; 3Konkuk University Hospital, Seoul, KoreaAims: To determine which risk factors for blindness w...

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Autores principales:	Karanjit S Kooner, Mohannad AlBdoor, Byung J Cho, Beverley Adams-Huet
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/3d0040d5945d4296b89a8562dd8478fc
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spelling	oai:doaj.org-article:3d0040d5945d4296b89a8562dd8478fc2021-12-02T00:40:10ZRisk factors for progression to blindness in high tension primary open angle glaucoma: Comparison of blind and nonblind subjects1177-54671177-5483https://doaj.org/article/3d0040d5945d4296b89a8562dd8478fc2008-08-01T00:00:00Zhttp://www.dovepress.com/risk-factors-for-progression-to-blindness-in-high-tension-primary-open-a1980https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Karanjit S Kooner1, Mohannad AlBdoor1, Byung J Cho3, Beverley Adams-Huet21Department of Ophthalmology, 2Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA; 3Konkuk University Hospital, Seoul, KoreaAims: To determine which risk factors for blindness were most critical in patients diagnosed with high tension primary open angle glaucoma (POAG) in a large ethnically diverse population managed with a uniform treatment strategy.Methods: A longitudinal observational study was designed to follow 487 patients (974 eyes) with POAG for an average of 5.5 &plusmn; 3.6 years. Detailed ocular and systemic information was collected on each patient and updated every six months. For this study, blindness was defined as visual acuity of 20/200 or worse and/or visual field less than 20&deg; in either eye. Known risk factors were compared between patients with blindness in at least one eye versus nonblind patients.Results: The patients with blindness had on average: higher intraocular pressure (IOP, mmHg): (24.2 &plusmn; 11.2 vs. 22.1 &plusmn; 7.7, p = 0.03), wide variation of IOP in the follow-up period (5.9 vs. 4.1 mmHg, p = 0.031), late detection (p = 0.006), poor control of IOP (p &lt; 0.0001), and noncompliance (p &lt; 0.0003). Other known risk factors such as race, age, myopia, family history of glaucoma, history of ocular trauma, hypertension, diabetes, vascular disease, smoking, alcohol abuse, dysthyoidism, and steroid use were not significant.Conclusions: The most critical factors associated with the development of blindness among our patients were: elevated initial IOP, wide variations and poor control of IOP, late detection of glaucoma, and noncompliance with therapy.Keywords: primary open angle glaucoma, blindness, intraocular pressure, risk factors, and noncompliance Karanjit S KoonerMohannad AlBdoorByung J ChoBeverley Adams-HuetDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 4, Pp 757-762 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Karanjit S Kooner Mohannad AlBdoor Byung J Cho Beverley Adams-Huet Risk factors for progression to blindness in high tension primary open angle glaucoma: Comparison of blind and nonblind subjects
description	Karanjit S Kooner1, Mohannad AlBdoor1, Byung J Cho3, Beverley Adams-Huet21Department of Ophthalmology, 2Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA; 3Konkuk University Hospital, Seoul, KoreaAims: To determine which risk factors for blindness were most critical in patients diagnosed with high tension primary open angle glaucoma (POAG) in a large ethnically diverse population managed with a uniform treatment strategy.Methods: A longitudinal observational study was designed to follow 487 patients (974 eyes) with POAG for an average of 5.5 &plusmn; 3.6 years. Detailed ocular and systemic information was collected on each patient and updated every six months. For this study, blindness was defined as visual acuity of 20/200 or worse and/or visual field less than 20&deg; in either eye. Known risk factors were compared between patients with blindness in at least one eye versus nonblind patients.Results: The patients with blindness had on average: higher intraocular pressure (IOP, mmHg): (24.2 &plusmn; 11.2 vs. 22.1 &plusmn; 7.7, p = 0.03), wide variation of IOP in the follow-up period (5.9 vs. 4.1 mmHg, p = 0.031), late detection (p = 0.006), poor control of IOP (p &lt; 0.0001), and noncompliance (p &lt; 0.0003). Other known risk factors such as race, age, myopia, family history of glaucoma, history of ocular trauma, hypertension, diabetes, vascular disease, smoking, alcohol abuse, dysthyoidism, and steroid use were not significant.Conclusions: The most critical factors associated with the development of blindness among our patients were: elevated initial IOP, wide variations and poor control of IOP, late detection of glaucoma, and noncompliance with therapy.Keywords: primary open angle glaucoma, blindness, intraocular pressure, risk factors, and noncompliance
format	article
author	Karanjit S Kooner Mohannad AlBdoor Byung J Cho Beverley Adams-Huet
author_facet	Karanjit S Kooner Mohannad AlBdoor Byung J Cho Beverley Adams-Huet
author_sort	Karanjit S Kooner
title	Risk factors for progression to blindness in high tension primary open angle glaucoma: Comparison of blind and nonblind subjects
title_short	Risk factors for progression to blindness in high tension primary open angle glaucoma: Comparison of blind and nonblind subjects
title_full	Risk factors for progression to blindness in high tension primary open angle glaucoma: Comparison of blind and nonblind subjects
title_fullStr	Risk factors for progression to blindness in high tension primary open angle glaucoma: Comparison of blind and nonblind subjects
title_full_unstemmed	Risk factors for progression to blindness in high tension primary open angle glaucoma: Comparison of blind and nonblind subjects
title_sort	risk factors for progression to blindness in high tension primary open angle glaucoma: comparison of blind and nonblind subjects
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/3d0040d5945d4296b89a8562dd8478fc
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Risk factors for progression to blindness in high tension primary open angle glaucoma: Comparison of blind and nonblind subjects

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