The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities

Apoptotic initiator caspases are thought to be activated through homodimerization but this remains controversial. Here the authors demonstrate that caspase-9 can adopt two distinct conformations within the Apaf-1 apoptosome, each with distinct properties that contribute to the overall function of th...

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Autores principales:	Chu-Chiao Wu, Sunhee Lee, Srinivas Malladi, Miao-Der Chen, Nicholas J. Mastrandrea, Zhiwen Zhang, Shawn B. Bratton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d0127db2c6e47c1b48d6022cb92b4e4
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spelling	oai:doaj.org-article:3d0127db2c6e47c1b48d6022cb92b4e42021-12-02T14:40:12ZThe Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities10.1038/ncomms135652041-1723https://doaj.org/article/3d0127db2c6e47c1b48d6022cb92b4e42016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13565https://doaj.org/toc/2041-1723Apoptotic initiator caspases are thought to be activated through homodimerization but this remains controversial. Here the authors demonstrate that caspase-9 can adopt two distinct conformations within the Apaf-1 apoptosome, each with distinct properties that contribute to the overall function of the complex.Chu-Chiao WuSunhee LeeSrinivas MalladiMiao-Der ChenNicholas J. MastrandreaZhiwen ZhangShawn B. BrattonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chu-Chiao Wu Sunhee Lee Srinivas Malladi Miao-Der Chen Nicholas J. Mastrandrea Zhiwen Zhang Shawn B. Bratton The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
description	Apoptotic initiator caspases are thought to be activated through homodimerization but this remains controversial. Here the authors demonstrate that caspase-9 can adopt two distinct conformations within the Apaf-1 apoptosome, each with distinct properties that contribute to the overall function of the complex.
format	article
author	Chu-Chiao Wu Sunhee Lee Srinivas Malladi Miao-Der Chen Nicholas J. Mastrandrea Zhiwen Zhang Shawn B. Bratton
author_facet	Chu-Chiao Wu Sunhee Lee Srinivas Malladi Miao-Der Chen Nicholas J. Mastrandrea Zhiwen Zhang Shawn B. Bratton
author_sort	Chu-Chiao Wu
title	The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
title_short	The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
title_full	The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
title_fullStr	The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
title_full_unstemmed	The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
title_sort	apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3d0127db2c6e47c1b48d6022cb92b4e4
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The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities

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