NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia

NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia

NFAT2 is a transcription factor that has been linked with chronic lymphocytic leukaemia (CLL), but its functions in CLL manifestation are still unclear. Here the authors show, by analysing mouse CLL models and characterising biopsies from CLL patients, that NFAT2 is an important regulator for the an...

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Autores principales: Melanie Märklin, Jonas S. Heitmann, Alexander R. Fuchs, Felicia M. Truckenmüller, Michael Gutknecht, Stefanie Bugl, Sebastian J. Saur, Juliane Lazarus, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Hans-Georg Rammensee, Helmut R. Salih, Hans-Georg Kopp, Michael Haap, Andreas Kirschniak, Lothar Kanz, Anjana Rao, Stefan Wirths, Martin R. Müller
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/3d01d0e5fd30417aa6c380e7daff8c86
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Sumario:NFAT2 is a transcription factor that has been linked with chronic lymphocytic leukaemia (CLL), but its functions in CLL manifestation are still unclear. Here the authors show, by analysing mouse CLL models and characterising biopsies from CLL patients, that NFAT2 is an important regulator for the anergic phenotype of CLL.

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