NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia

NFAT2 is a transcription factor that has been linked with chronic lymphocytic leukaemia (CLL), but its functions in CLL manifestation are still unclear. Here the authors show, by analysing mouse CLL models and characterising biopsies from CLL patients, that NFAT2 is an important regulator for the an...

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Autores principales:	Melanie Märklin, Jonas S. Heitmann, Alexander R. Fuchs, Felicia M. Truckenmüller, Michael Gutknecht, Stefanie Bugl, Sebastian J. Saur, Juliane Lazarus, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Hans-Georg Rammensee, Helmut R. Salih, Hans-Georg Kopp, Michael Haap, Andreas Kirschniak, Lothar Kanz, Anjana Rao, Stefan Wirths, Martin R. Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d01d0e5fd30417aa6c380e7daff8c86
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spelling	oai:doaj.org-article:3d01d0e5fd30417aa6c380e7daff8c862021-12-02T14:41:59ZNFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia10.1038/s41467-017-00830-y2041-1723https://doaj.org/article/3d01d0e5fd30417aa6c380e7daff8c862017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00830-yhttps://doaj.org/toc/2041-1723NFAT2 is a transcription factor that has been linked with chronic lymphocytic leukaemia (CLL), but its functions in CLL manifestation are still unclear. Here the authors show, by analysing mouse CLL models and characterising biopsies from CLL patients, that NFAT2 is an important regulator for the anergic phenotype of CLL.Melanie MärklinJonas S. HeitmannAlexander R. FuchsFelicia M. TruckenmüllerMichael GutknechtStefanie BuglSebastian J. SaurJuliane LazarusUrsula KohlhoferLeticia Quintanilla-MartinezHans-Georg RammenseeHelmut R. SalihHans-Georg KoppMichael HaapAndreas KirschniakLothar KanzAnjana RaoStefan WirthsMartin R. MüllerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melanie Märklin Jonas S. Heitmann Alexander R. Fuchs Felicia M. Truckenmüller Michael Gutknecht Stefanie Bugl Sebastian J. Saur Juliane Lazarus Ursula Kohlhofer Leticia Quintanilla-Martinez Hans-Georg Rammensee Helmut R. Salih Hans-Georg Kopp Michael Haap Andreas Kirschniak Lothar Kanz Anjana Rao Stefan Wirths Martin R. Müller NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia
description	NFAT2 is a transcription factor that has been linked with chronic lymphocytic leukaemia (CLL), but its functions in CLL manifestation are still unclear. Here the authors show, by analysing mouse CLL models and characterising biopsies from CLL patients, that NFAT2 is an important regulator for the anergic phenotype of CLL.
format	article
author	Melanie Märklin Jonas S. Heitmann Alexander R. Fuchs Felicia M. Truckenmüller Michael Gutknecht Stefanie Bugl Sebastian J. Saur Juliane Lazarus Ursula Kohlhofer Leticia Quintanilla-Martinez Hans-Georg Rammensee Helmut R. Salih Hans-Georg Kopp Michael Haap Andreas Kirschniak Lothar Kanz Anjana Rao Stefan Wirths Martin R. Müller
author_facet	Melanie Märklin Jonas S. Heitmann Alexander R. Fuchs Felicia M. Truckenmüller Michael Gutknecht Stefanie Bugl Sebastian J. Saur Juliane Lazarus Ursula Kohlhofer Leticia Quintanilla-Martinez Hans-Georg Rammensee Helmut R. Salih Hans-Georg Kopp Michael Haap Andreas Kirschniak Lothar Kanz Anjana Rao Stefan Wirths Martin R. Müller
author_sort	Melanie Märklin
title	NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia
title_short	NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia
title_full	NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia
title_fullStr	NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia
title_full_unstemmed	NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia
title_sort	nfat2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3d01d0e5fd30417aa6c380e7daff8c86
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NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia

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