E2F1 regulates cellular growth by mTORC1 signaling.
During cell proliferation, growth must occur to maintain homeostatic cell size. Here we show that E2F1 is capable of inducing growth by regulating mTORC1 activity. The activation of cell growth and mTORC1 by E2F1 is dependent on both E2F1's ability to bind DNA and to regulate gene transcription...
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| Auteurs principaux: | , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2011
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/3d027ccf9f644fbcb2fd354895d61cc4 |
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