Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme

Abstract Glioblastoma multiforme (GBM) is the most frequent type of primary astrocytomas. We examined the association between single nucleotide polymorphisms (SNPs) in Aurora kinase A (AURKA), Aurora kinase B (AURKB), Aurora kinase C (AURKC) and Polo-like kinase 1 (PLK1) mitotic checkpoint genes and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aner Mesic, Marija Rogar, Petra Hudler, Nurija Bilalovic, Izet Eminovic, Radovan Komel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d032d90c06b44ca8574eb384bf7b4db
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3d032d90c06b44ca8574eb384bf7b4db
record_format	dspace
spelling	oai:doaj.org-article:3d032d90c06b44ca8574eb384bf7b4db2021-12-02T15:28:52ZGenetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme10.1038/s41598-021-96935-y2045-2322https://doaj.org/article/3d032d90c06b44ca8574eb384bf7b4db2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96935-yhttps://doaj.org/toc/2045-2322Abstract Glioblastoma multiforme (GBM) is the most frequent type of primary astrocytomas. We examined the association between single nucleotide polymorphisms (SNPs) in Aurora kinase A (AURKA), Aurora kinase B (AURKB), Aurora kinase C (AURKC) and Polo-like kinase 1 (PLK1) mitotic checkpoint genes and GBM risk by qPCR genotyping. In silico analysis was performed to evaluate effects of polymorphic biological sequences on protein binding motifs. Chi-square and Fisher statistics revealed a significant difference in genotypes frequencies between GBM patients and controls for AURKB rs2289590 variant (p = 0.038). Association with decreased GBM risk was demonstrated for AURKB rs2289590 AC genotype (OR = 0.54; 95% CI = 0.33–0.88; p = 0.015). Furthermore, AURKC rs11084490 CG genotype was associated with lower GBM risk (OR = 0.57; 95% CI = 0.34–0.95; p = 0.031). Bioinformatic analysis of rs2289590 polymorphic region identified additional binding site for the Yin-Yang 1 (YY1) transcription factor in the presence of C allele. Our results indicated that rs2289590 in AURKB and rs11084490 in AURKC were associated with a reduced GBM risk. The present study was performed on a less numerous but ethnically homogeneous population. Hence, future investigations in larger and multiethnic groups are needed to strengthen these results.Aner MesicMarija RogarPetra HudlerNurija BilalovicIzet EminovicRadovan KomelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aner Mesic Marija Rogar Petra Hudler Nurija Bilalovic Izet Eminovic Radovan Komel Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme
description	Abstract Glioblastoma multiforme (GBM) is the most frequent type of primary astrocytomas. We examined the association between single nucleotide polymorphisms (SNPs) in Aurora kinase A (AURKA), Aurora kinase B (AURKB), Aurora kinase C (AURKC) and Polo-like kinase 1 (PLK1) mitotic checkpoint genes and GBM risk by qPCR genotyping. In silico analysis was performed to evaluate effects of polymorphic biological sequences on protein binding motifs. Chi-square and Fisher statistics revealed a significant difference in genotypes frequencies between GBM patients and controls for AURKB rs2289590 variant (p = 0.038). Association with decreased GBM risk was demonstrated for AURKB rs2289590 AC genotype (OR = 0.54; 95% CI = 0.33–0.88; p = 0.015). Furthermore, AURKC rs11084490 CG genotype was associated with lower GBM risk (OR = 0.57; 95% CI = 0.34–0.95; p = 0.031). Bioinformatic analysis of rs2289590 polymorphic region identified additional binding site for the Yin-Yang 1 (YY1) transcription factor in the presence of C allele. Our results indicated that rs2289590 in AURKB and rs11084490 in AURKC were associated with a reduced GBM risk. The present study was performed on a less numerous but ethnically homogeneous population. Hence, future investigations in larger and multiethnic groups are needed to strengthen these results.
format	article
author	Aner Mesic Marija Rogar Petra Hudler Nurija Bilalovic Izet Eminovic Radovan Komel
author_facet	Aner Mesic Marija Rogar Petra Hudler Nurija Bilalovic Izet Eminovic Radovan Komel
author_sort	Aner Mesic
title	Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme
title_short	Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme
title_full	Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme
title_fullStr	Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme
title_full_unstemmed	Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme
title_sort	genetic variations in aurora cell cycle kinases are associated with glioblastoma multiforme
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d032d90c06b44ca8574eb384bf7b4db
work_keys_str_mv	AT anermesic geneticvariationsinauroracellcyclekinasesareassociatedwithglioblastomamultiforme AT marijarogar geneticvariationsinauroracellcyclekinasesareassociatedwithglioblastomamultiforme AT petrahudler geneticvariationsinauroracellcyclekinasesareassociatedwithglioblastomamultiforme AT nurijabilalovic geneticvariationsinauroracellcyclekinasesareassociatedwithglioblastomamultiforme AT izeteminovic geneticvariationsinauroracellcyclekinasesareassociatedwithglioblastomamultiforme AT radovankomel geneticvariationsinauroracellcyclekinasesareassociatedwithglioblastomamultiforme
_version_	1718387197347889152

Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme

Ejemplares similares