Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma

Abstract To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-sou...

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Autores principales:	Ruyue Shen, Yu Meng Wang, Carol Y. Cheung, Poemen P. Chan, Clement C. Tham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d0439492acd42f2bf92fcdf36085f9d
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spelling	oai:doaj.org-article:3d0439492acd42f2bf92fcdf36085f9d2021-12-05T12:14:22ZComparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma10.1038/s41598-021-02296-x2045-2322https://doaj.org/article/3d0439492acd42f2bf92fcdf36085f9d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02296-xhttps://doaj.org/toc/2045-2322Abstract To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined. Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369 ± 0.781%) compared with PACG eyes (55.389 ± 0.721%, P = 0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis revealed that, for PACG and NTG eyes, decreased cpVD ([PACG] β = −4.242; CI: −8.120, −0.363 vs [NTG] β = −5.531; CI: −9.472, −1.590) and cpFD ([PACG] β = −8.894;CI: −11.925, −5.864 vs [NTG] β = −12.064; CI: −17.095, −6.932) were associated with decreased RNFL thickness (all P ≤ 0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (P = 0.028). Decreased cpVD was associated with decrease mean deviation (MD) in NTG eyes (β = −0.707; CI: −1.090, −0.324; P ≤ 0.001) and not associated with the visual field parameters in PACG eyes. Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.Ruyue ShenYu Meng WangCarol Y. CheungPoemen P. ChanClement C. ThamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruyue Shen Yu Meng Wang Carol Y. Cheung Poemen P. Chan Clement C. Tham Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma
description	Abstract To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined. Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369 ± 0.781%) compared with PACG eyes (55.389 ± 0.721%, P = 0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis revealed that, for PACG and NTG eyes, decreased cpVD ([PACG] β = −4.242; CI: −8.120, −0.363 vs [NTG] β = −5.531; CI: −9.472, −1.590) and cpFD ([PACG] β = −8.894;CI: −11.925, −5.864 vs [NTG] β = −12.064; CI: −17.095, −6.932) were associated with decreased RNFL thickness (all P ≤ 0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (P = 0.028). Decreased cpVD was associated with decrease mean deviation (MD) in NTG eyes (β = −0.707; CI: −1.090, −0.324; P ≤ 0.001) and not associated with the visual field parameters in PACG eyes. Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.
format	article
author	Ruyue Shen Yu Meng Wang Carol Y. Cheung Poemen P. Chan Clement C. Tham
author_facet	Ruyue Shen Yu Meng Wang Carol Y. Cheung Poemen P. Chan Clement C. Tham
author_sort	Ruyue Shen
title	Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma
title_short	Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma
title_full	Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma
title_fullStr	Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma
title_full_unstemmed	Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma
title_sort	comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d0439492acd42f2bf92fcdf36085f9d
work_keys_str_mv	AT ruyueshen comparisonofopticalcoherencetomographyangiographymetricsinprimaryangleclosureglaucomaandnormaltensionglaucoma AT yumengwang comparisonofopticalcoherencetomographyangiographymetricsinprimaryangleclosureglaucomaandnormaltensionglaucoma AT carolycheung comparisonofopticalcoherencetomographyangiographymetricsinprimaryangleclosureglaucomaandnormaltensionglaucoma AT poemenpchan comparisonofopticalcoherencetomographyangiographymetricsinprimaryangleclosureglaucomaandnormaltensionglaucoma AT clementctham comparisonofopticalcoherencetomographyangiographymetricsinprimaryangleclosureglaucomaandnormaltensionglaucoma
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Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma

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