Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta

Abstract Horizontal gene transfer (HGT), the movement of heritable materials between distantly related organisms, is crucial in eukaryotic evolution. However, the scale of HGT in choanoflagellates, the closest unicellular relatives of metazoans, and its possible roles in the evolution of animal mult...

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Autores principales:	Danielle M. Matriano, Rosanna A. Alegado, Cecilia Conaco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d044552cd454681a80acb7cc74ac780
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spelling	oai:doaj.org-article:3d044552cd454681a80acb7cc74ac7802021-12-02T11:39:27ZDetection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta10.1038/s41598-021-85259-62045-2322https://doaj.org/article/3d044552cd454681a80acb7cc74ac7802021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85259-6https://doaj.org/toc/2045-2322Abstract Horizontal gene transfer (HGT), the movement of heritable materials between distantly related organisms, is crucial in eukaryotic evolution. However, the scale of HGT in choanoflagellates, the closest unicellular relatives of metazoans, and its possible roles in the evolution of animal multicellularity remains unexplored. We identified at least 175 candidate HGTs in the genome of the colonial choanoflagellate Salpingoeca rosetta using sequence-based tests. The majority of these were orthologous to genes in bacterial and microalgal lineages, yet displayed genomic features consistent with the rest of the S. rosetta genome—evidence of ancient acquisition events. Putative functions include enzymes involved in amino acid and carbohydrate metabolism, cell signaling, and the synthesis of extracellular matrix components. Functions of candidate HGTs may have contributed to the ability of choanoflagellates to assimilate novel metabolites, thereby supporting adaptation, survival in diverse ecological niches, and response to external cues that are possibly critical in the evolution of multicellularity in choanoflagellates.Danielle M. MatrianoRosanna A. AlegadoCecilia ConacoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danielle M. Matriano Rosanna A. Alegado Cecilia Conaco Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta
description	Abstract Horizontal gene transfer (HGT), the movement of heritable materials between distantly related organisms, is crucial in eukaryotic evolution. However, the scale of HGT in choanoflagellates, the closest unicellular relatives of metazoans, and its possible roles in the evolution of animal multicellularity remains unexplored. We identified at least 175 candidate HGTs in the genome of the colonial choanoflagellate Salpingoeca rosetta using sequence-based tests. The majority of these were orthologous to genes in bacterial and microalgal lineages, yet displayed genomic features consistent with the rest of the S. rosetta genome—evidence of ancient acquisition events. Putative functions include enzymes involved in amino acid and carbohydrate metabolism, cell signaling, and the synthesis of extracellular matrix components. Functions of candidate HGTs may have contributed to the ability of choanoflagellates to assimilate novel metabolites, thereby supporting adaptation, survival in diverse ecological niches, and response to external cues that are possibly critical in the evolution of multicellularity in choanoflagellates.
format	article
author	Danielle M. Matriano Rosanna A. Alegado Cecilia Conaco
author_facet	Danielle M. Matriano Rosanna A. Alegado Cecilia Conaco
author_sort	Danielle M. Matriano
title	Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta
title_short	Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta
title_full	Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta
title_fullStr	Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta
title_full_unstemmed	Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta
title_sort	detection of horizontal gene transfer in the genome of the choanoflagellate salpingoeca rosetta
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d044552cd454681a80acb7cc74ac780
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Detection of horizontal gene transfer in the genome of the choanoflagellate Salpingoeca rosetta

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