Highly enantioselective catalytic synthesis of chiral pyridines

Chiral pyridines are valuable building blocks in medicinal chemistry applications. Here, the authors report the copper-catalysed Lewis acid-assisted asymmetric alkylation of β-substituted alkenyl pyridines with Grignard reagents affording chiral pyridines with excellent enantioselectivity.

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Autores principales:	Ravindra P. Jumde, Francesco Lanza, Tilde Pellegrini, Syuzanna R. Harutyunyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d04506799974370a2a83d18e52554d3
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spelling	oai:doaj.org-article:3d04506799974370a2a83d18e52554d32021-12-02T17:06:18ZHighly enantioselective catalytic synthesis of chiral pyridines10.1038/s41467-017-01966-72041-1723https://doaj.org/article/3d04506799974370a2a83d18e52554d32017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01966-7https://doaj.org/toc/2041-1723Chiral pyridines are valuable building blocks in medicinal chemistry applications. Here, the authors report the copper-catalysed Lewis acid-assisted asymmetric alkylation of β-substituted alkenyl pyridines with Grignard reagents affording chiral pyridines with excellent enantioselectivity.Ravindra P. JumdeFrancesco LanzaTilde PellegriniSyuzanna R. HarutyunyanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ravindra P. Jumde Francesco Lanza Tilde Pellegrini Syuzanna R. Harutyunyan Highly enantioselective catalytic synthesis of chiral pyridines
description	Chiral pyridines are valuable building blocks in medicinal chemistry applications. Here, the authors report the copper-catalysed Lewis acid-assisted asymmetric alkylation of β-substituted alkenyl pyridines with Grignard reagents affording chiral pyridines with excellent enantioselectivity.
format	article
author	Ravindra P. Jumde Francesco Lanza Tilde Pellegrini Syuzanna R. Harutyunyan
author_facet	Ravindra P. Jumde Francesco Lanza Tilde Pellegrini Syuzanna R. Harutyunyan
author_sort	Ravindra P. Jumde
title	Highly enantioselective catalytic synthesis of chiral pyridines
title_short	Highly enantioselective catalytic synthesis of chiral pyridines
title_full	Highly enantioselective catalytic synthesis of chiral pyridines
title_fullStr	Highly enantioselective catalytic synthesis of chiral pyridines
title_full_unstemmed	Highly enantioselective catalytic synthesis of chiral pyridines
title_sort	highly enantioselective catalytic synthesis of chiral pyridines
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3d04506799974370a2a83d18e52554d3
work_keys_str_mv	AT ravindrapjumde highlyenantioselectivecatalyticsynthesisofchiralpyridines AT francescolanza highlyenantioselectivecatalyticsynthesisofchiralpyridines AT tildepellegrini highlyenantioselectivecatalyticsynthesisofchiralpyridines AT syuzannarharutyunyan highlyenantioselectivecatalyticsynthesisofchiralpyridines
_version_	1718381666985050112

Highly enantioselective catalytic synthesis of chiral pyridines

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