Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians
Lebriz Altay,1 Cheryl Jahn,1 Mücella Arikan Yorgun,1 Albert Caramoy,1 Tina Schick,1 Carel B Hoyng,2 Anneke I den Hollander,2 Sascha Fauser1 1Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 2Department of Ophthalmology, Radboud University Nijmegen Medical Cent...
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Dove Medical Press
2017
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oai:doaj.org-article:3d079b4776c74d969c335357f264ffe72021-12-02T03:15:26ZAlteration of retinal layers in healthy subjects over 60 years of age until nonagenarians1177-5483https://doaj.org/article/3d079b4776c74d969c335357f264ffe72017-08-01T00:00:00Zhttps://www.dovepress.com/alteration-of-retinal-layers-in-healthy-subjects-over-60-years-of-age--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Lebriz Altay,1 Cheryl Jahn,1 Mücella Arikan Yorgun,1 Albert Caramoy,1 Tina Schick,1 Carel B Hoyng,2 Anneke I den Hollander,2 Sascha Fauser1 1Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 2Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands Purpose: To assess alterations of retinal layers in healthy subjects over 60 years old. Methods: Retinal layers of 160 healthy subjects (aged 60–100 years) without any retinal pathology were imaged using spectral domain optical coherence tomography. Mean thickness of retinal nerve fiber layer, ganglion cell/inner plexiform layer (GCLIPL), inner nuclear layer, outer plexiform layer/outer nuclear layer, photoreceptor complex (PR) and retinal thickness (RT) were measured in a 3.45 mm grid. Correlations between age and layers were estimated and linear regression equations were calculated. Different age-groups (60–69, 70–79, 80–89 years and nonagenarians, each group with 40 participants) were compared. Results: Significant age-thickness correlations were observed for GCLIPL (P<0.001, r=-0.394), PR (P<0.001, r=-0.370) and RT (P<0.001, r=-0.290). A comparison between age groups 60–69 years and nonagenarians showed no significant thickness alteration of retinal nerve fiber layer (21.80±2.18 µm vs 22.82±2.97 µm, P=0.163), inner nuclear layer (37.23±3.02 µm vs 36.01±3.24 µm, P=0.07) and outer plexiform layer/outer nuclear layer (104.95±6.56 µm vs 104.23±7.59 µm, P=0.567), while GCLIPL (83.35±7.35 µm vs 74.38±9.09 µm), PR (83.03±3.31 µm vs 79.34±2.09 µm) and RT (330.64±12.63 µm vs 316.83±18.35 µm) showed a significant decrease (P<0.001 for all). Conclusion: Our study provides normative data of alterations of retinal layers for persons aged 60 years to nonagenarians and indicates a continuous decrease of RT, PR, and GCLIPL. This data may be useful for clinical trials investigating macular diseases in older patients. Keywords: nonagenarians, SDOCT, retinal thickness, very elderly, photoreceptor, healthyAltay LJahn CArikan Yorgun MCaramoy ASchick THoyng CBden Hollander AIFauser SDove Medical PressarticleNonagenariansSDOCTretinal thicknessvery elderlyphotoreceptorhealthyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1499-1503 (2017) |
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DOAJ |
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Nonagenarians SDOCT retinal thickness very elderly photoreceptor healthy Ophthalmology RE1-994 |
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Nonagenarians SDOCT retinal thickness very elderly photoreceptor healthy Ophthalmology RE1-994 Altay L Jahn C Arikan Yorgun M Caramoy A Schick T Hoyng CB den Hollander AI Fauser S Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians |
| description |
Lebriz Altay,1 Cheryl Jahn,1 Mücella Arikan Yorgun,1 Albert Caramoy,1 Tina Schick,1 Carel B Hoyng,2 Anneke I den Hollander,2 Sascha Fauser1 1Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 2Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands Purpose: To assess alterations of retinal layers in healthy subjects over 60 years old. Methods: Retinal layers of 160 healthy subjects (aged 60–100 years) without any retinal pathology were imaged using spectral domain optical coherence tomography. Mean thickness of retinal nerve fiber layer, ganglion cell/inner plexiform layer (GCLIPL), inner nuclear layer, outer plexiform layer/outer nuclear layer, photoreceptor complex (PR) and retinal thickness (RT) were measured in a 3.45 mm grid. Correlations between age and layers were estimated and linear regression equations were calculated. Different age-groups (60–69, 70–79, 80–89 years and nonagenarians, each group with 40 participants) were compared. Results: Significant age-thickness correlations were observed for GCLIPL (P<0.001, r=-0.394), PR (P<0.001, r=-0.370) and RT (P<0.001, r=-0.290). A comparison between age groups 60–69 years and nonagenarians showed no significant thickness alteration of retinal nerve fiber layer (21.80±2.18 µm vs 22.82±2.97 µm, P=0.163), inner nuclear layer (37.23±3.02 µm vs 36.01±3.24 µm, P=0.07) and outer plexiform layer/outer nuclear layer (104.95±6.56 µm vs 104.23±7.59 µm, P=0.567), while GCLIPL (83.35±7.35 µm vs 74.38±9.09 µm), PR (83.03±3.31 µm vs 79.34±2.09 µm) and RT (330.64±12.63 µm vs 316.83±18.35 µm) showed a significant decrease (P<0.001 for all). Conclusion: Our study provides normative data of alterations of retinal layers for persons aged 60 years to nonagenarians and indicates a continuous decrease of RT, PR, and GCLIPL. This data may be useful for clinical trials investigating macular diseases in older patients. Keywords: nonagenarians, SDOCT, retinal thickness, very elderly, photoreceptor, healthy |
| format |
article |
| author |
Altay L Jahn C Arikan Yorgun M Caramoy A Schick T Hoyng CB den Hollander AI Fauser S |
| author_facet |
Altay L Jahn C Arikan Yorgun M Caramoy A Schick T Hoyng CB den Hollander AI Fauser S |
| author_sort |
Altay L |
| title |
Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians |
| title_short |
Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians |
| title_full |
Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians |
| title_fullStr |
Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians |
| title_full_unstemmed |
Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians |
| title_sort |
alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/3d079b4776c74d969c335357f264ffe7 |
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