Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light

Adil M Allahverdiyev1, Emrah Sefik Abamor1, Malahat Bagirova1, Cem B Ustundag2, Cengiz Kaya2, Figen Kaya2, Miriam Rafailovich3 1Department of Bioengineering; 2Department of Metallurgical and Materials Engineering, Yildiz Technical University, Esenler, Istanbul, Turkey; 3Department of Materials Scien...

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Autores principales:	Allahverdiyev AM, Abamor ES, Bagirova M, Ustundag CB, Kaya C, Kaya F, Rafailovich M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3d08767084534104974cfd57eb650de6
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spelling	oai:doaj.org-article:3d08767084534104974cfd57eb650de62021-12-02T05:10:24ZAntileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light1176-91141178-2013https://doaj.org/article/3d08767084534104974cfd57eb650de62011-11-01T00:00:00Zhttp://www.dovepress.com/antileishmanial-effect-of-silver-nanoparticles-and-their-enhanced-anti-a8593https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Adil M Allahverdiyev1, Emrah Sefik Abamor1, Malahat Bagirova1, Cem B Ustundag2, Cengiz Kaya2, Figen Kaya2, Miriam Rafailovich3 1Department of Bioengineering; 2Department of Metallurgical and Materials Engineering, Yildiz Technical University, Esenler, Istanbul, Turkey; 3Department of Materials Science and Engineering, Stony Brook University, Stony Brook, NY, USA Abstract: Leishmaniasis is a protozoan vector-borne disease and is one of the biggest health problems of the world. Antileishmanial drugs have disadvantages such as toxicity and the recent development of resistance. One of the best-known mechanisms of the antibacterial effects of silver nanoparticles (Ag-NPs) is the production of reactive oxygen species to which Leishmania parasites are very sensitive. So far no information about the effects of Ag-NPs on Leishmania tropica parasites, the causative agent of leishmaniasis, exists in the literature. The aim of this study was to investigate the effects of Ag-NPs on biological parameters of L. tropica such as morphology, metabolic activity, proliferation, infectivity, and survival in host cells, in vitro. Consequently, parasite morphology and infectivity were impaired in comparison with the control. Also, enhanced effects of Ag-NPs were demonstrated on the morphology and infectivity of parasites under ultraviolet (UV) light. Ag-NPs demonstrated significant antileishmanial effects by inhibiting the proliferation and metabolic activity of promastigotes by 1.5- to threefold, respectively, in the dark, and 2- to 6.5-fold, respectively, under UV light. Of note, Ag-NPs inhibited the survival of amastigotes in host cells, and this effect was more significant in the presence of UV light. Thus, for the first time the antileishmanial effects of Ag-NPs on L. tropica parasites were demonstrated along with the enhanced antimicrobial activity of Ag-NPs under UV light. Determination of the antileishmanial effects of Ag-NPs is very important for the further development of new compounds containing nanoparticles in leishmaniasis treatment. Keywords: nanotechnology, leishmaniasis, Leishmania, parasiteAllahverdiyev AMAbamor ESBagirova MUstundag CBKaya CKaya FRafailovich MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2705-2714 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Allahverdiyev AM Abamor ES Bagirova M Ustundag CB Kaya C Kaya F Rafailovich M Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light
description	Adil M Allahverdiyev1, Emrah Sefik Abamor1, Malahat Bagirova1, Cem B Ustundag2, Cengiz Kaya2, Figen Kaya2, Miriam Rafailovich3 1Department of Bioengineering; 2Department of Metallurgical and Materials Engineering, Yildiz Technical University, Esenler, Istanbul, Turkey; 3Department of Materials Science and Engineering, Stony Brook University, Stony Brook, NY, USA Abstract: Leishmaniasis is a protozoan vector-borne disease and is one of the biggest health problems of the world. Antileishmanial drugs have disadvantages such as toxicity and the recent development of resistance. One of the best-known mechanisms of the antibacterial effects of silver nanoparticles (Ag-NPs) is the production of reactive oxygen species to which Leishmania parasites are very sensitive. So far no information about the effects of Ag-NPs on Leishmania tropica parasites, the causative agent of leishmaniasis, exists in the literature. The aim of this study was to investigate the effects of Ag-NPs on biological parameters of L. tropica such as morphology, metabolic activity, proliferation, infectivity, and survival in host cells, in vitro. Consequently, parasite morphology and infectivity were impaired in comparison with the control. Also, enhanced effects of Ag-NPs were demonstrated on the morphology and infectivity of parasites under ultraviolet (UV) light. Ag-NPs demonstrated significant antileishmanial effects by inhibiting the proliferation and metabolic activity of promastigotes by 1.5- to threefold, respectively, in the dark, and 2- to 6.5-fold, respectively, under UV light. Of note, Ag-NPs inhibited the survival of amastigotes in host cells, and this effect was more significant in the presence of UV light. Thus, for the first time the antileishmanial effects of Ag-NPs on L. tropica parasites were demonstrated along with the enhanced antimicrobial activity of Ag-NPs under UV light. Determination of the antileishmanial effects of Ag-NPs is very important for the further development of new compounds containing nanoparticles in leishmaniasis treatment. Keywords: nanotechnology, leishmaniasis, Leishmania, parasite
format	article
author	Allahverdiyev AM Abamor ES Bagirova M Ustundag CB Kaya C Kaya F Rafailovich M
author_facet	Allahverdiyev AM Abamor ES Bagirova M Ustundag CB Kaya C Kaya F Rafailovich M
author_sort	Allahverdiyev AM
title	Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light
title_short	Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light
title_full	Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light
title_fullStr	Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light
title_full_unstemmed	Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light
title_sort	antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/3d08767084534104974cfd57eb650de6
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Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light

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