The Flo Adhesin Family
The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their invol...
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MDPI AG
2021
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oai:doaj.org-article:3d11c6a25556471aa428da09afc2bc8c2021-11-25T18:37:54ZThe Flo Adhesin Family10.3390/pathogens101113972076-0817https://doaj.org/article/3d11c6a25556471aa428da09afc2bc8c2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1397https://doaj.org/toc/2076-0817The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechanisms of the Flo adhesins whose structure has been solved are discussed in detail. Finally, we identified from Pfam database datamining yeasts that could express Flo adhesins and are encountered in human infections and their adhesin architectures. These yeasts are discussed in relation to their adhesion characteristics and involvement in infections.Ronnie G. WillaertYeseren KayacanBart DevreeseMDPI AGarticleFlo adhesin familypathogenic yeasts<i>Candida glabrata</i><i>Saccharomyces cerevisiae</i>host-pathogen interactionabiotic surface adhesionMedicineRENPathogens, Vol 10, Iss 1397, p 1397 (2021) |
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Flo adhesin family pathogenic yeasts <i>Candida glabrata</i> <i>Saccharomyces cerevisiae</i> host-pathogen interaction abiotic surface adhesion Medicine R |
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Flo adhesin family pathogenic yeasts <i>Candida glabrata</i> <i>Saccharomyces cerevisiae</i> host-pathogen interaction abiotic surface adhesion Medicine R Ronnie G. Willaert Yeseren Kayacan Bart Devreese The Flo Adhesin Family |
description |
The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechanisms of the Flo adhesins whose structure has been solved are discussed in detail. Finally, we identified from Pfam database datamining yeasts that could express Flo adhesins and are encountered in human infections and their adhesin architectures. These yeasts are discussed in relation to their adhesion characteristics and involvement in infections. |
format |
article |
author |
Ronnie G. Willaert Yeseren Kayacan Bart Devreese |
author_facet |
Ronnie G. Willaert Yeseren Kayacan Bart Devreese |
author_sort |
Ronnie G. Willaert |
title |
The Flo Adhesin Family |
title_short |
The Flo Adhesin Family |
title_full |
The Flo Adhesin Family |
title_fullStr |
The Flo Adhesin Family |
title_full_unstemmed |
The Flo Adhesin Family |
title_sort |
flo adhesin family |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/3d11c6a25556471aa428da09afc2bc8c |
work_keys_str_mv |
AT ronniegwillaert thefloadhesinfamily AT yeserenkayacan thefloadhesinfamily AT bartdevreese thefloadhesinfamily AT ronniegwillaert floadhesinfamily AT yeserenkayacan floadhesinfamily AT bartdevreese floadhesinfamily |
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1718410887708016640 |