The Flo Adhesin Family

The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their invol...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ronnie G. Willaert, Yeseren Kayacan, Bart Devreese
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
R
Acceso en línea:https://doaj.org/article/3d11c6a25556471aa428da09afc2bc8c
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:3d11c6a25556471aa428da09afc2bc8c
record_format dspace
spelling oai:doaj.org-article:3d11c6a25556471aa428da09afc2bc8c2021-11-25T18:37:54ZThe Flo Adhesin Family10.3390/pathogens101113972076-0817https://doaj.org/article/3d11c6a25556471aa428da09afc2bc8c2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1397https://doaj.org/toc/2076-0817The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechanisms of the Flo adhesins whose structure has been solved are discussed in detail. Finally, we identified from Pfam database datamining yeasts that could express Flo adhesins and are encountered in human infections and their adhesin architectures. These yeasts are discussed in relation to their adhesion characteristics and involvement in infections.Ronnie G. WillaertYeseren KayacanBart DevreeseMDPI AGarticleFlo adhesin familypathogenic yeasts<i>Candida glabrata</i><i>Saccharomyces cerevisiae</i>host-pathogen interactionabiotic surface adhesionMedicineRENPathogens, Vol 10, Iss 1397, p 1397 (2021)
institution DOAJ
collection DOAJ
language EN
topic Flo adhesin family
pathogenic yeasts
<i>Candida glabrata</i>
<i>Saccharomyces cerevisiae</i>
host-pathogen interaction
abiotic surface adhesion
Medicine
R
spellingShingle Flo adhesin family
pathogenic yeasts
<i>Candida glabrata</i>
<i>Saccharomyces cerevisiae</i>
host-pathogen interaction
abiotic surface adhesion
Medicine
R
Ronnie G. Willaert
Yeseren Kayacan
Bart Devreese
The Flo Adhesin Family
description The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechanisms of the Flo adhesins whose structure has been solved are discussed in detail. Finally, we identified from Pfam database datamining yeasts that could express Flo adhesins and are encountered in human infections and their adhesin architectures. These yeasts are discussed in relation to their adhesion characteristics and involvement in infections.
format article
author Ronnie G. Willaert
Yeseren Kayacan
Bart Devreese
author_facet Ronnie G. Willaert
Yeseren Kayacan
Bart Devreese
author_sort Ronnie G. Willaert
title The Flo Adhesin Family
title_short The Flo Adhesin Family
title_full The Flo Adhesin Family
title_fullStr The Flo Adhesin Family
title_full_unstemmed The Flo Adhesin Family
title_sort flo adhesin family
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/3d11c6a25556471aa428da09afc2bc8c
work_keys_str_mv AT ronniegwillaert thefloadhesinfamily
AT yeserenkayacan thefloadhesinfamily
AT bartdevreese thefloadhesinfamily
AT ronniegwillaert floadhesinfamily
AT yeserenkayacan floadhesinfamily
AT bartdevreese floadhesinfamily
_version_ 1718410887708016640