Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts

Dry skin is one of the indicators of a compromised skin barrier. An intact skin barrier is not only important to reserve the hydration within the epidermal tissue but also to protect our skin from environmental stressors and inhibit pathogen invasion; damage to the skin barrier may lead to inflammat...

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Autores principales:	Haryung Park, Karina Arellano, Yuri Lee, Subin Yeo, Yosep Ji, Joontae Ko, Wilhelm Holzapfel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Cutibacterium</i> diversity dry moist short chain fatty acids skin microbiome Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3d153317f89e4ce5924363261ade5733
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spelling	oai:doaj.org-article:3d153317f89e4ce5924363261ade57332021-11-25T18:24:18ZPilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts10.3390/microorganisms91122162076-2607https://doaj.org/article/3d153317f89e4ce5924363261ade57332021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2216https://doaj.org/toc/2076-2607Dry skin is one of the indicators of a compromised skin barrier. An intact skin barrier is not only important to reserve the hydration within the epidermal tissue but also to protect our skin from environmental stressors and inhibit pathogen invasion; damage to the skin barrier may lead to inflammatory skin diseases. Some microbial metabolites such as short chain fatty acids may inhibit or destroy harmful bacteria and regulate the host immune system. The impact of the skin microbiome and short chain fatty acids on skin barrier function was studied in two groups of 75 participants each. The cohort was equally divided in dry and moist skin types, based on stratum corneum (SC) functionality index (SCFI), reflecting the ratio of transepidermal water loss (TEWL). A dry group represents a low SCFI and a moist group a high SCFI. Compared with the dry skin group, propionate and <i>Cutibacterium</i> levels (previously known as <i>Propionibacterium acnes</i>) were significantly higher (<i>p</i> < 0.001) in the moist group. Levels of <i>Cutibacterium</i> were negatively correlated with those of <i>Staphylococcus</i> (<i>p</i> < 0.0001) in both dry and moist groups. The moist group also had a significantly higher propionate concentration (<i>p</i> < 0.001). This study showed that the microbial community and short chain fatty acid concentration may be considered as significant determinants of the SCFI of the skin.Haryung ParkKarina ArellanoYuri LeeSubin YeoYosep JiJoontae KoWilhelm HolzapfelMDPI AGarticle<i>Cutibacterium</i>diversitydrymoistshort chain fatty acidsskin microbiomeBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2216, p 2216 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Cutibacterium</i> diversity dry moist short chain fatty acids skin microbiome Biology (General) QH301-705.5
spellingShingle	<i>Cutibacterium</i> diversity dry moist short chain fatty acids skin microbiome Biology (General) QH301-705.5 Haryung Park Karina Arellano Yuri Lee Subin Yeo Yosep Ji Joontae Ko Wilhelm Holzapfel Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts
description	Dry skin is one of the indicators of a compromised skin barrier. An intact skin barrier is not only important to reserve the hydration within the epidermal tissue but also to protect our skin from environmental stressors and inhibit pathogen invasion; damage to the skin barrier may lead to inflammatory skin diseases. Some microbial metabolites such as short chain fatty acids may inhibit or destroy harmful bacteria and regulate the host immune system. The impact of the skin microbiome and short chain fatty acids on skin barrier function was studied in two groups of 75 participants each. The cohort was equally divided in dry and moist skin types, based on stratum corneum (SC) functionality index (SCFI), reflecting the ratio of transepidermal water loss (TEWL). A dry group represents a low SCFI and a moist group a high SCFI. Compared with the dry skin group, propionate and <i>Cutibacterium</i> levels (previously known as <i>Propionibacterium acnes</i>) were significantly higher (<i>p</i> < 0.001) in the moist group. Levels of <i>Cutibacterium</i> were negatively correlated with those of <i>Staphylococcus</i> (<i>p</i> < 0.0001) in both dry and moist groups. The moist group also had a significantly higher propionate concentration (<i>p</i> < 0.001). This study showed that the microbial community and short chain fatty acid concentration may be considered as significant determinants of the SCFI of the skin.
format	article
author	Haryung Park Karina Arellano Yuri Lee Subin Yeo Yosep Ji Joontae Ko Wilhelm Holzapfel
author_facet	Haryung Park Karina Arellano Yuri Lee Subin Yeo Yosep Ji Joontae Ko Wilhelm Holzapfel
author_sort	Haryung Park
title	Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts
title_short	Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts
title_full	Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts
title_fullStr	Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts
title_full_unstemmed	Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts
title_sort	pilot study on the forehead skin microbiome and short chain fatty acids depending on the sc functional index in korean cohorts
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3d153317f89e4ce5924363261ade5733
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Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts

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