The role of APOE in cognitive trajectories and motor decline in Parkinson’s disease

Abstract We aimed to investigate the role of the APOE genotype in cognitive and motor trajectories in Parkinson’s disease (PD). Using PD registry data, we retrospectively investigated a total of 253 patients with PD who underwent the Mini-Mental State Exam (MMSE) two or more times at least 5 years a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sungyang Jo, Seon-Ok Kim, Kye Won Park, Seung Hyun Lee, Yun Su Hwang, Sun Ju Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d179007cd2b43c8a89aeb77af9197dc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3d179007cd2b43c8a89aeb77af9197dc
record_format	dspace
spelling	oai:doaj.org-article:3d179007cd2b43c8a89aeb77af9197dc2021-12-02T14:22:43ZThe role of APOE in cognitive trajectories and motor decline in Parkinson’s disease10.1038/s41598-021-86483-w2045-2322https://doaj.org/article/3d179007cd2b43c8a89aeb77af9197dc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86483-whttps://doaj.org/toc/2045-2322Abstract We aimed to investigate the role of the APOE genotype in cognitive and motor trajectories in Parkinson’s disease (PD). Using PD registry data, we retrospectively investigated a total of 253 patients with PD who underwent the Mini-Mental State Exam (MMSE) two or more times at least 5 years apart, were aged over 40 years, and free of dementia at the time of enrollment. We performed group-based trajectory modeling to identify patterns of cognitive change using the MMSE. Kaplan–Meier survival analysis was used to investigate the role of the APOE genotype in cognitive and motor progression. Trajectory analysis divided patients into four groups: early fast decline, fast decline, gradual decline, and stable groups with annual MMSE scores decline of − 2.8, − 1.8, − 0.6, and − 0.1 points per year, respectively. The frequency of APOE ε4 was higher in patients in the early fast decline and fast decline groups (50.0%) than those in the stable group (20.1%) (p = 0.007). APOE ε4, in addition to older age at onset, depressive mood, and higher H&Y stage, was associated with the cognitive decline rate, but no APOE genotype was associated with motor progression. APOE genotype could be used to predict the cognitive trajectory in PD.Sungyang JoSeon-Ok KimKye Won ParkSeung Hyun LeeYun Su HwangSun Ju ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sungyang Jo Seon-Ok Kim Kye Won Park Seung Hyun Lee Yun Su Hwang Sun Ju Chung The role of APOE in cognitive trajectories and motor decline in Parkinson’s disease
description	Abstract We aimed to investigate the role of the APOE genotype in cognitive and motor trajectories in Parkinson’s disease (PD). Using PD registry data, we retrospectively investigated a total of 253 patients with PD who underwent the Mini-Mental State Exam (MMSE) two or more times at least 5 years apart, were aged over 40 years, and free of dementia at the time of enrollment. We performed group-based trajectory modeling to identify patterns of cognitive change using the MMSE. Kaplan–Meier survival analysis was used to investigate the role of the APOE genotype in cognitive and motor progression. Trajectory analysis divided patients into four groups: early fast decline, fast decline, gradual decline, and stable groups with annual MMSE scores decline of − 2.8, − 1.8, − 0.6, and − 0.1 points per year, respectively. The frequency of APOE ε4 was higher in patients in the early fast decline and fast decline groups (50.0%) than those in the stable group (20.1%) (p = 0.007). APOE ε4, in addition to older age at onset, depressive mood, and higher H&Y stage, was associated with the cognitive decline rate, but no APOE genotype was associated with motor progression. APOE genotype could be used to predict the cognitive trajectory in PD.
format	article
author	Sungyang Jo Seon-Ok Kim Kye Won Park Seung Hyun Lee Yun Su Hwang Sun Ju Chung
author_facet	Sungyang Jo Seon-Ok Kim Kye Won Park Seung Hyun Lee Yun Su Hwang Sun Ju Chung
author_sort	Sungyang Jo
title	The role of APOE in cognitive trajectories and motor decline in Parkinson’s disease
title_short	The role of APOE in cognitive trajectories and motor decline in Parkinson’s disease
title_full	The role of APOE in cognitive trajectories and motor decline in Parkinson’s disease
title_fullStr	The role of APOE in cognitive trajectories and motor decline in Parkinson’s disease
title_full_unstemmed	The role of APOE in cognitive trajectories and motor decline in Parkinson’s disease
title_sort	role of apoe in cognitive trajectories and motor decline in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d179007cd2b43c8a89aeb77af9197dc
work_keys_str_mv	AT sungyangjo theroleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT seonokkim theroleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT kyewonpark theroleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT seunghyunlee theroleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT yunsuhwang theroleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT sunjuchung theroleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT sungyangjo roleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT seonokkim roleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT kyewonpark roleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT seunghyunlee roleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT yunsuhwang roleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease AT sunjuchung roleofapoeincognitivetrajectoriesandmotordeclineinparkinsonsdisease
_version_	1718391480873123840

The role of APOE in cognitive trajectories and motor decline in Parkinson’s disease

Ejemplares similares