Peripartum Antibiotics Exposure and the Risk of Autoimmune and Autism Disorders in the Offspring

Background As the use of antibiotics during the peripartum period increases, the incidence of autoimmune disorders and autism spectrum disorders (ASDs) is also increasing. In this study, we aim to assess if antibiotic exposure during the peripartum period affects the incidence of autoimmune diseases...

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Autores principales:	Jehad Almasri, Ahmed Barazi, Katherine S. King, Marina R. S. Walther-Antonio, Zhen Wang, Mohammad H. Murad, Joseph A. Murray, Imad Absah
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Materias:	antibiotics exposure in pregnancy autism autoimmune disease microbiome Medicine R
Acceso en línea:	https://doaj.org/article/3d184f1968c8461cb9ea78b57cdc351f
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spelling	oai:doaj.org-article:3d184f1968c8461cb9ea78b57cdc351f2021-12-02T18:32:47ZPeripartum Antibiotics Exposure and the Risk of Autoimmune and Autism Disorders in the Offspring2231-07702249-446410.1055/s-0041-1732485https://doaj.org/article/3d184f1968c8461cb9ea78b57cdc351f2021-08-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1732485https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Background As the use of antibiotics during the peripartum period increases, the incidence of autoimmune disorders and autism spectrum disorders (ASDs) is also increasing. In this study, we aim to assess if antibiotic exposure during the peripartum period affects the incidence of autoimmune diseases and ASD in the offspring. Methods We identified children (< 18 years of age) born in Olmsted County from January 1, 2003 through December 31, 2012. Offspring with celiac disease (CD), inflammatory bowel disease (IBD), or ASD diagnoses were matched to two controls on birth date, index date, mother’s age at delivery, and sex. Data from the mother’s medical records were retrieved to determine peripartum antibiotics use. Results A total of 242 cases and 484 matched controls were included in this study. Median age at the last follow-up was 11.3 years (range: 0.5–14.9), 73% were males in both groups. Odds of CD diagnosis was not statistically different between vaginal delivery with antibiotics compared with vaginal delivery with no antibiotics (odds ratio [OR] = 0.76, 95% confidence interval [CI]: 0.32–1.85), similarly in IBD (OR = 2.41, 95% CI: 0.53–10.98) and ASD (OR = 1.00, 95% CI:0.55–1.79). Preeclampsia or eclampsia was associated with offspring CD (OR = 3.20, 95% CI: 1.05–9.78). Smoking history and diabetes mellitus were associated with offspring ASD (OR = 1.84, 95% CI: 1.22–2.77 and OR = 2.01, 95% CI: 1.03–3.91, respectively). Conclusion In this cohort, we found no statistically significant association between peripartum antibiotics exposure and the development of CD, IBD, or ASD.Jehad AlmasriAhmed BaraziKatherine S. KingMarina R. S. Walther-AntonioZhen WangMohammad H. MuradJoseph A. MurrayImad AbsahThieme Medical and Scientific Publishers Pvt. Ltd.articleantibiotics exposure in pregnancyautismautoimmune diseasemicrobiomeMedicineRENAvicenna Journal of Medicine, Vol 11, Iss 03, Pp 118-125 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotics exposure in pregnancy autism autoimmune disease microbiome Medicine R
spellingShingle	antibiotics exposure in pregnancy autism autoimmune disease microbiome Medicine R Jehad Almasri Ahmed Barazi Katherine S. King Marina R. S. Walther-Antonio Zhen Wang Mohammad H. Murad Joseph A. Murray Imad Absah Peripartum Antibiotics Exposure and the Risk of Autoimmune and Autism Disorders in the Offspring
description	Background As the use of antibiotics during the peripartum period increases, the incidence of autoimmune disorders and autism spectrum disorders (ASDs) is also increasing. In this study, we aim to assess if antibiotic exposure during the peripartum period affects the incidence of autoimmune diseases and ASD in the offspring. Methods We identified children (< 18 years of age) born in Olmsted County from January 1, 2003 through December 31, 2012. Offspring with celiac disease (CD), inflammatory bowel disease (IBD), or ASD diagnoses were matched to two controls on birth date, index date, mother’s age at delivery, and sex. Data from the mother’s medical records were retrieved to determine peripartum antibiotics use. Results A total of 242 cases and 484 matched controls were included in this study. Median age at the last follow-up was 11.3 years (range: 0.5–14.9), 73% were males in both groups. Odds of CD diagnosis was not statistically different between vaginal delivery with antibiotics compared with vaginal delivery with no antibiotics (odds ratio [OR] = 0.76, 95% confidence interval [CI]: 0.32–1.85), similarly in IBD (OR = 2.41, 95% CI: 0.53–10.98) and ASD (OR = 1.00, 95% CI:0.55–1.79). Preeclampsia or eclampsia was associated with offspring CD (OR = 3.20, 95% CI: 1.05–9.78). Smoking history and diabetes mellitus were associated with offspring ASD (OR = 1.84, 95% CI: 1.22–2.77 and OR = 2.01, 95% CI: 1.03–3.91, respectively). Conclusion In this cohort, we found no statistically significant association between peripartum antibiotics exposure and the development of CD, IBD, or ASD.
format	article
author	Jehad Almasri Ahmed Barazi Katherine S. King Marina R. S. Walther-Antonio Zhen Wang Mohammad H. Murad Joseph A. Murray Imad Absah
author_facet	Jehad Almasri Ahmed Barazi Katherine S. King Marina R. S. Walther-Antonio Zhen Wang Mohammad H. Murad Joseph A. Murray Imad Absah
author_sort	Jehad Almasri
title	Peripartum Antibiotics Exposure and the Risk of Autoimmune and Autism Disorders in the Offspring
title_short	Peripartum Antibiotics Exposure and the Risk of Autoimmune and Autism Disorders in the Offspring
title_full	Peripartum Antibiotics Exposure and the Risk of Autoimmune and Autism Disorders in the Offspring
title_fullStr	Peripartum Antibiotics Exposure and the Risk of Autoimmune and Autism Disorders in the Offspring
title_full_unstemmed	Peripartum Antibiotics Exposure and the Risk of Autoimmune and Autism Disorders in the Offspring
title_sort	peripartum antibiotics exposure and the risk of autoimmune and autism disorders in the offspring
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2021
url	https://doaj.org/article/3d184f1968c8461cb9ea78b57cdc351f
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Peripartum Antibiotics Exposure and the Risk of Autoimmune and Autism Disorders in the Offspring

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