The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice
Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which is associated with improved glucose tolerance.
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Nature Portfolio
2020
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oai:doaj.org-article:3d1a44c22d254ecbacf92a2ba8dc772e2021-12-02T15:52:53ZThe CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice10.1038/s41467-020-16347-w2041-1723https://doaj.org/article/3d1a44c22d254ecbacf92a2ba8dc772e2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16347-whttps://doaj.org/toc/2041-1723Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which is associated with improved glucose tolerance.Shota YoshidaHironori NakagamiHiroki HayashiYuka IkedaJiao SunAkiko TenmaHideki TomiokaTomohiro KawanoMunehisa ShimamuraRyuichi MorishitaHiromi RakugiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Shota Yoshida Hironori Nakagami Hiroki Hayashi Yuka Ikeda Jiao Sun Akiko Tenma Hideki Tomioka Tomohiro Kawano Munehisa Shimamura Ryuichi Morishita Hiromi Rakugi The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice |
| description |
Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which is associated with improved glucose tolerance. |
| format |
article |
| author |
Shota Yoshida Hironori Nakagami Hiroki Hayashi Yuka Ikeda Jiao Sun Akiko Tenma Hideki Tomioka Tomohiro Kawano Munehisa Shimamura Ryuichi Morishita Hiromi Rakugi |
| author_facet |
Shota Yoshida Hironori Nakagami Hiroki Hayashi Yuka Ikeda Jiao Sun Akiko Tenma Hideki Tomioka Tomohiro Kawano Munehisa Shimamura Ryuichi Morishita Hiromi Rakugi |
| author_sort |
Shota Yoshida |
| title |
The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice |
| title_short |
The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice |
| title_full |
The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice |
| title_fullStr |
The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice |
| title_full_unstemmed |
The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice |
| title_sort |
cd153 vaccine is a senotherapeutic option for preventing the accumulation of senescent t cells in mice |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/3d1a44c22d254ecbacf92a2ba8dc772e |
| work_keys_str_mv |
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1718385564510584832 |