Tuberculosis Arthritis in the Wrist While Using Rituximab for Rheumatoid Arthritis Treatment

Hasan Ulusoy,1 Özge Acar Cakan,1 Tibel Tuna2 1Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey; 2Department of Pulmonary Medicine and Tuberculosis, Faculty of Medicine, Ondokuz Mayis University, Samsu...

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Autores principales:	Ulusoy H, Acar Cakan O, Tuna T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	rheumatoid arthritis rituximab tuberculosis infection Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/3d1d0865dd6e4eb9bc0ff9e59f1df2b3
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spelling	oai:doaj.org-article:3d1d0865dd6e4eb9bc0ff9e59f1df2b32021-12-02T10:19:19ZTuberculosis Arthritis in the Wrist While Using Rituximab for Rheumatoid Arthritis Treatment1179-156Xhttps://doaj.org/article/3d1d0865dd6e4eb9bc0ff9e59f1df2b32020-09-01T00:00:00Zhttps://www.dovepress.com/tuberculosis-arthritis-in-the-wrist-while-using-rituximab-for-rheumato-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XHasan Ulusoy,1 Özge Acar Cakan,1 Tibel Tuna2 1Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey; 2Department of Pulmonary Medicine and Tuberculosis, Faculty of Medicine, Ondokuz Mayis University, Samsun, TurkeyCorrespondence: Hasan UlusoyOndokuz Mayis Universitesi, Tip Fakultesi, Romatoloji Bilimdali, Fiziksel Tip ve Rehabilitasyon AD, Samsun 55200, TurkeyTel +90 534 074 05 55Email drhasanulusoy@gmail.comIntroduction: Data from clinical trials indicate that there are no increased risk of tuberculosis (TB) infections in rheumatoid arthritis (RA) patients while using rituximab (RTX). Herein, we report a RA patient who developed TB arthritis while using RTX.Case Report: A 49-year-old patient was treated with methotrexate and prednisolone along with RTX for two years. Later, she presented with increasing pain, swelling, redness and cutaneous fistulization in her left wrist for two months. The lesion on the wrist was debritted. Histopathologic evaluation revealed the presence of acid-fast bacilli. Polymerase chain reaction test and culture confirmed mycobacterium tuberculosis. RTX, methotrexate and prednisolone were withdrawn. The patient was treated with 12-month course of antituberculous treatment and responded well. The patient, who did not have pain or swelling in her other joints, was not given any treatment for RA after antituberculous treatment.Conclusion: Clinicians should keep in mind that TB infections may be encountered while using RTX. Latent TB screening may be appropriate in patients using concomitant corticosteroid and living in TB endemic areas.Keywords: rheumatoid arthritis, rituximab, tuberculosis, infectionUlusoy HAcar Cakan OTuna TDove Medical Pressarticlerheumatoid arthritisrituximabtuberculosisinfectionDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 203-206 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis rituximab tuberculosis infection Diseases of the musculoskeletal system RC925-935
spellingShingle	rheumatoid arthritis rituximab tuberculosis infection Diseases of the musculoskeletal system RC925-935 Ulusoy H Acar Cakan O Tuna T Tuberculosis Arthritis in the Wrist While Using Rituximab for Rheumatoid Arthritis Treatment
description	Hasan Ulusoy,1 Özge Acar Cakan,1 Tibel Tuna2 1Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey; 2Department of Pulmonary Medicine and Tuberculosis, Faculty of Medicine, Ondokuz Mayis University, Samsun, TurkeyCorrespondence: Hasan UlusoyOndokuz Mayis Universitesi, Tip Fakultesi, Romatoloji Bilimdali, Fiziksel Tip ve Rehabilitasyon AD, Samsun 55200, TurkeyTel +90 534 074 05 55Email drhasanulusoy@gmail.comIntroduction: Data from clinical trials indicate that there are no increased risk of tuberculosis (TB) infections in rheumatoid arthritis (RA) patients while using rituximab (RTX). Herein, we report a RA patient who developed TB arthritis while using RTX.Case Report: A 49-year-old patient was treated with methotrexate and prednisolone along with RTX for two years. Later, she presented with increasing pain, swelling, redness and cutaneous fistulization in her left wrist for two months. The lesion on the wrist was debritted. Histopathologic evaluation revealed the presence of acid-fast bacilli. Polymerase chain reaction test and culture confirmed mycobacterium tuberculosis. RTX, methotrexate and prednisolone were withdrawn. The patient was treated with 12-month course of antituberculous treatment and responded well. The patient, who did not have pain or swelling in her other joints, was not given any treatment for RA after antituberculous treatment.Conclusion: Clinicians should keep in mind that TB infections may be encountered while using RTX. Latent TB screening may be appropriate in patients using concomitant corticosteroid and living in TB endemic areas.Keywords: rheumatoid arthritis, rituximab, tuberculosis, infection
format	article
author	Ulusoy H Acar Cakan O Tuna T
author_facet	Ulusoy H Acar Cakan O Tuna T
author_sort	Ulusoy H
title	Tuberculosis Arthritis in the Wrist While Using Rituximab for Rheumatoid Arthritis Treatment
title_short	Tuberculosis Arthritis in the Wrist While Using Rituximab for Rheumatoid Arthritis Treatment
title_full	Tuberculosis Arthritis in the Wrist While Using Rituximab for Rheumatoid Arthritis Treatment
title_fullStr	Tuberculosis Arthritis in the Wrist While Using Rituximab for Rheumatoid Arthritis Treatment
title_full_unstemmed	Tuberculosis Arthritis in the Wrist While Using Rituximab for Rheumatoid Arthritis Treatment
title_sort	tuberculosis arthritis in the wrist while using rituximab for rheumatoid arthritis treatment
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/3d1d0865dd6e4eb9bc0ff9e59f1df2b3
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Tuberculosis Arthritis in the Wrist While Using Rituximab for Rheumatoid Arthritis Treatment

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