HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia
Nucleophosmin (NPM1) gene mutation induces a specific gene expression program leading to acute myeloid leukaemia. Here, the authors show that mutant NPM1 activates a HOXB locus-associated long non-coding RNA which is essential for its associated oncogenic transcriptional program and leukaemia develo...
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Nature Portfolio
2021
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oai:doaj.org-article:3d1f0106667c417191762bec7de144502021-12-02T14:23:30ZHOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia10.1038/s41467-021-22095-22041-1723https://doaj.org/article/3d1f0106667c417191762bec7de144502021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22095-2https://doaj.org/toc/2041-1723Nucleophosmin (NPM1) gene mutation induces a specific gene expression program leading to acute myeloid leukaemia. Here, the authors show that mutant NPM1 activates a HOXB locus-associated long non-coding RNA which is essential for its associated oncogenic transcriptional program and leukaemia development.Ganqian ZhuHuacheng LuoYang FengOlga A. GuryanovaJianfeng XuShi ChenQian LaiArati SharmaBing XuZhigang ZhaoRu FengHongyu NiDavid ClaxtonYing GuoRuben A. MesaYi QiuFeng-Chun YangWei LiStephen D. NimerSuming HuangMingjiang XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ganqian Zhu Huacheng Luo Yang Feng Olga A. Guryanova Jianfeng Xu Shi Chen Qian Lai Arati Sharma Bing Xu Zhigang Zhao Ru Feng Hongyu Ni David Claxton Ying Guo Ruben A. Mesa Yi Qiu Feng-Chun Yang Wei Li Stephen D. Nimer Suming Huang Mingjiang Xu HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia |
| description |
Nucleophosmin (NPM1) gene mutation induces a specific gene expression program leading to acute myeloid leukaemia. Here, the authors show that mutant NPM1 activates a HOXB locus-associated long non-coding RNA which is essential for its associated oncogenic transcriptional program and leukaemia development. |
| format |
article |
| author |
Ganqian Zhu Huacheng Luo Yang Feng Olga A. Guryanova Jianfeng Xu Shi Chen Qian Lai Arati Sharma Bing Xu Zhigang Zhao Ru Feng Hongyu Ni David Claxton Ying Guo Ruben A. Mesa Yi Qiu Feng-Chun Yang Wei Li Stephen D. Nimer Suming Huang Mingjiang Xu |
| author_facet |
Ganqian Zhu Huacheng Luo Yang Feng Olga A. Guryanova Jianfeng Xu Shi Chen Qian Lai Arati Sharma Bing Xu Zhigang Zhao Ru Feng Hongyu Ni David Claxton Ying Guo Ruben A. Mesa Yi Qiu Feng-Chun Yang Wei Li Stephen D. Nimer Suming Huang Mingjiang Xu |
| author_sort |
Ganqian Zhu |
| title |
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia |
| title_short |
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia |
| title_full |
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia |
| title_fullStr |
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia |
| title_full_unstemmed |
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia |
| title_sort |
hoxblinc long non-coding rna activation promotes leukemogenesis in npm1-mutant acute myeloid leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3d1f0106667c417191762bec7de14450 |
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