ROLE OF IL-4, IL-6, IL-8, IL-10 CYTOKINES IN THE IMMUNOPATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Chronic obstructive pulmonary disease (COPD) is socially significant disease. COPD is based on chronic inflammatory process of respiratory tract, which determines steady progression of the bronchial obstruction. Studies of the role of cytokines in immune pathogenesis of COPD are of crucial importanc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	E. Yu. Trushina, E. M. Kostina, B. A. Molotilov, V. A. Tipikin, N. I. Baranova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	chronic obstructive pulmonary disease copd cytokines fev1 eosinophilic inflammation neutrophilic inflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3d21cfaccf4e43f5aa21c136684697fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3d21cfaccf4e43f5aa21c136684697fe
record_format	dspace
spelling	oai:doaj.org-article:3d21cfaccf4e43f5aa21c136684697fe2021-11-18T08:03:48ZROLE OF IL-4, IL-6, IL-8, IL-10 CYTOKINES IN THE IMMUNOPATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE1563-06252313-741X10.15789/1563-0625-2019-1-89-98https://doaj.org/article/3d21cfaccf4e43f5aa21c136684697fe2019-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1702https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XChronic obstructive pulmonary disease (COPD) is socially significant disease. COPD is based on chronic inflammatory process of respiratory tract, which determines steady progression of the bronchial obstruction. Studies of the role of cytokines in immune pathogenesis of COPD are of crucial importance. The biological mediators determine local, systemic inflammation, and pathophysiological effects of extra-systemic pathological manifestations. In this work, we studied spontaneous and induced production of IL-4, IL-6, IL-8, IL-10 cytokines by blood leukocytes from the patients with moderate and severe chronic obstructive pulmonary disease, beyond the exacerbation phase. It is shown that the evident role in formation of the inflammatory process in COPD belongs to the IL-6, IL-8. We have found a significant increase in both spontaneous and induced production of IL-6 and IL-8 (p < 0.05) in the patients. Induced production of cytokines strongly suggests the reserve capabilities of immunocompetent cells in response to the pathogenic factor. Neutrophilic type of inflammation, manifesting as activation of granulocytes, mostly, neutrophils, in response to toxic agents (in particular, smoking) and bacterial pathogens, is primarily associated with IL-6 and IL-8. These results reflect the type and intensity of respiratory tract inflammation in patients with chronic obstructive pulmonary disease and its persistent course.High levels of the studied cytokines confirm their role in bronchial remodeling and contribute to irreversibility of bronchial obstruction in this disorder. The relationship between spontaneous and induced production of the studied cytokines and the clinical indices of the disease course has been shown. Statistically significant increase between frequency of COPD recurrences (more than 2 times pro year, p < 0.05), and low FEV1 values (p < 0.05) were observed in patients with high values of spontaneous and induced production of IL-6 and IL-8. It may be associated with persistent course of neutrophilic inflammation of respiratory tract and progressive bronchial obstruction. IL-6 and IL-8 significantly contribute to pathogenetic mechanisms, determining the clinical course of COPD and may serve as markers of severity in this disorder. Certainly, the immune mechanisms of pathological inflammation in COPD are complex and multifaceted. Studies of clinical significance of induced cytokine production will help the physician when determining type and duration of treatment. Personalized approach to the therapy of patients with COPD depends on the phenotype of pathology, pattern, severity and intensity of inflammation.E. Yu. TrushinaE. M. KostinaB. A. MolotilovV. A. TipikinN. I. BaranovaSPb RAACIarticlechronic obstructive pulmonary diseasecopdcytokinesfev1eosinophilic inflammationneutrophilic inflammationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 1, Pp 89-98 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic obstructive pulmonary disease copd cytokines fev1 eosinophilic inflammation neutrophilic inflammation Immunologic diseases. Allergy RC581-607
spellingShingle	chronic obstructive pulmonary disease copd cytokines fev1 eosinophilic inflammation neutrophilic inflammation Immunologic diseases. Allergy RC581-607 E. Yu. Trushina E. M. Kostina B. A. Molotilov V. A. Tipikin N. I. Baranova ROLE OF IL-4, IL-6, IL-8, IL-10 CYTOKINES IN THE IMMUNOPATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
description	Chronic obstructive pulmonary disease (COPD) is socially significant disease. COPD is based on chronic inflammatory process of respiratory tract, which determines steady progression of the bronchial obstruction. Studies of the role of cytokines in immune pathogenesis of COPD are of crucial importance. The biological mediators determine local, systemic inflammation, and pathophysiological effects of extra-systemic pathological manifestations. In this work, we studied spontaneous and induced production of IL-4, IL-6, IL-8, IL-10 cytokines by blood leukocytes from the patients with moderate and severe chronic obstructive pulmonary disease, beyond the exacerbation phase. It is shown that the evident role in formation of the inflammatory process in COPD belongs to the IL-6, IL-8. We have found a significant increase in both spontaneous and induced production of IL-6 and IL-8 (p < 0.05) in the patients. Induced production of cytokines strongly suggests the reserve capabilities of immunocompetent cells in response to the pathogenic factor. Neutrophilic type of inflammation, manifesting as activation of granulocytes, mostly, neutrophils, in response to toxic agents (in particular, smoking) and bacterial pathogens, is primarily associated with IL-6 and IL-8. These results reflect the type and intensity of respiratory tract inflammation in patients with chronic obstructive pulmonary disease and its persistent course.High levels of the studied cytokines confirm their role in bronchial remodeling and contribute to irreversibility of bronchial obstruction in this disorder. The relationship between spontaneous and induced production of the studied cytokines and the clinical indices of the disease course has been shown. Statistically significant increase between frequency of COPD recurrences (more than 2 times pro year, p < 0.05), and low FEV1 values (p < 0.05) were observed in patients with high values of spontaneous and induced production of IL-6 and IL-8. It may be associated with persistent course of neutrophilic inflammation of respiratory tract and progressive bronchial obstruction. IL-6 and IL-8 significantly contribute to pathogenetic mechanisms, determining the clinical course of COPD and may serve as markers of severity in this disorder. Certainly, the immune mechanisms of pathological inflammation in COPD are complex and multifaceted. Studies of clinical significance of induced cytokine production will help the physician when determining type and duration of treatment. Personalized approach to the therapy of patients with COPD depends on the phenotype of pathology, pattern, severity and intensity of inflammation.
format	article
author	E. Yu. Trushina E. M. Kostina B. A. Molotilov V. A. Tipikin N. I. Baranova
author_facet	E. Yu. Trushina E. M. Kostina B. A. Molotilov V. A. Tipikin N. I. Baranova
author_sort	E. Yu. Trushina
title	ROLE OF IL-4, IL-6, IL-8, IL-10 CYTOKINES IN THE IMMUNOPATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_short	ROLE OF IL-4, IL-6, IL-8, IL-10 CYTOKINES IN THE IMMUNOPATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_full	ROLE OF IL-4, IL-6, IL-8, IL-10 CYTOKINES IN THE IMMUNOPATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_fullStr	ROLE OF IL-4, IL-6, IL-8, IL-10 CYTOKINES IN THE IMMUNOPATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_full_unstemmed	ROLE OF IL-4, IL-6, IL-8, IL-10 CYTOKINES IN THE IMMUNOPATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_sort	role of il-4, il-6, il-8, il-10 cytokines in the immunopathogenesis of chronic obstructive pulmonary disease
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/3d21cfaccf4e43f5aa21c136684697fe
work_keys_str_mv	AT eyutrushina roleofil4il6il8il10cytokinesintheimmunopathogenesisofchronicobstructivepulmonarydisease AT emkostina roleofil4il6il8il10cytokinesintheimmunopathogenesisofchronicobstructivepulmonarydisease AT bamolotilov roleofil4il6il8il10cytokinesintheimmunopathogenesisofchronicobstructivepulmonarydisease AT vatipikin roleofil4il6il8il10cytokinesintheimmunopathogenesisofchronicobstructivepulmonarydisease AT nibaranova roleofil4il6il8il10cytokinesintheimmunopathogenesisofchronicobstructivepulmonarydisease
_version_	1718422343334756352

ROLE OF IL-4, IL-6, IL-8, IL-10 CYTOKINES IN THE IMMUNOPATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Ejemplares similares