Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy

Ramy M El Sabaa,1 Emad Hamdi,2,3 Nermin Aly Hamdy,4 Hatem A Sarhan5 1Clinical Pharmacy Department, Faculty of Pharmacy, Deraya University, Minia, Egypt; 2Deraya University President, Minia, Egypt; 3Psychiatry Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 4Neurology Department, Fac...

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Autores principales:	El Sabaa RM, Hamdi E, Hamdy NA, Sarhan HA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cognitive function epilepsy levetiracetam valproate monotherapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/3d2769f2bd7e44b79030cf9d8909323d
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spelling	oai:doaj.org-article:3d2769f2bd7e44b79030cf9d8909323d2021-12-02T10:14:52ZEffects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy1178-2021https://doaj.org/article/3d2769f2bd7e44b79030cf9d8909323d2020-08-01T00:00:00Zhttps://www.dovepress.com/effects-of-levetiracetam-compared-to-valproate-on-cognitive-functions--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ramy M El Sabaa,1 Emad Hamdi,2,3 Nermin Aly Hamdy,4 Hatem A Sarhan5 1Clinical Pharmacy Department, Faculty of Pharmacy, Deraya University, Minia, Egypt; 2Deraya University President, Minia, Egypt; 3Psychiatry Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 4Neurology Department, Faculty of Medicine, Minia University, Minia, Egypt; 5Pharmaceutics Department, Faculty of Pharmacy, Minia University, Minia, EgyptCorrespondence: Ramy M El SabaaClinical Pharmacy Department, Faculty of Pharmacy, Deraya University, Minia, New Minia 61768, EgyptTel +20-10-0635-0788Email dr.ramypharma@gmail.comObjective: This study compared the effect of levetiracetam (LEV) as monotherapy to sodium valproate (VPA) as monotherapy on cognitive functions in patients with epilepsy.Methods: This was a comparative prospective study on 50 patients with newly diagnosed epilepsy started on antiseizure medications. Patients were selected from the neurology-outpatient clinics at Minia University Hospital, Minia, Egypt. They were divided into two groups: group treated with LEV and group treated with VPA. All patients were subjected to cognitive function assessment using reaction-time tests, trail-making tests, and Wisconsin card-sorting test before treatment and 3 months after treatment.Results: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment.Conclusion: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment.Keywords: cognitive function, epilepsy, levetiracetam, valproate, monotherapyEl Sabaa RMHamdi EHamdy NASarhan HADove Medical Pressarticlecognitive functionepilepsylevetiracetamvalproatemonotherapyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1945-1953 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognitive function epilepsy levetiracetam valproate monotherapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	cognitive function epilepsy levetiracetam valproate monotherapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 El Sabaa RM Hamdi E Hamdy NA Sarhan HA Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy
description	Ramy M El Sabaa,1 Emad Hamdi,2,3 Nermin Aly Hamdy,4 Hatem A Sarhan5 1Clinical Pharmacy Department, Faculty of Pharmacy, Deraya University, Minia, Egypt; 2Deraya University President, Minia, Egypt; 3Psychiatry Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 4Neurology Department, Faculty of Medicine, Minia University, Minia, Egypt; 5Pharmaceutics Department, Faculty of Pharmacy, Minia University, Minia, EgyptCorrespondence: Ramy M El SabaaClinical Pharmacy Department, Faculty of Pharmacy, Deraya University, Minia, New Minia 61768, EgyptTel +20-10-0635-0788Email dr.ramypharma@gmail.comObjective: This study compared the effect of levetiracetam (LEV) as monotherapy to sodium valproate (VPA) as monotherapy on cognitive functions in patients with epilepsy.Methods: This was a comparative prospective study on 50 patients with newly diagnosed epilepsy started on antiseizure medications. Patients were selected from the neurology-outpatient clinics at Minia University Hospital, Minia, Egypt. They were divided into two groups: group treated with LEV and group treated with VPA. All patients were subjected to cognitive function assessment using reaction-time tests, trail-making tests, and Wisconsin card-sorting test before treatment and 3 months after treatment.Results: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment.Conclusion: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment.Keywords: cognitive function, epilepsy, levetiracetam, valproate, monotherapy
format	article
author	El Sabaa RM Hamdi E Hamdy NA Sarhan HA
author_facet	El Sabaa RM Hamdi E Hamdy NA Sarhan HA
author_sort	El Sabaa RM
title	Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy
title_short	Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy
title_full	Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy
title_fullStr	Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy
title_full_unstemmed	Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy
title_sort	effects of levetiracetam compared to valproate on cognitive functions of patients with epilepsy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/3d2769f2bd7e44b79030cf9d8909323d
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_version_	1718397457952407552

Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy

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