Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes
Induction of tolerance in the gut relies on immunomodulatory functions of mesenteric lymph nodes (mLN). Here the authors show that mLN stromal cells receive early microbiota imprinting in the neonatal phase to exhibit long-term, location-specific transcriptional programs for the induction of regulat...
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Nature Portfolio
2018
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oai:doaj.org-article:3d292c2802f1404fac2cc90eb9e52fbb2021-12-02T16:50:10ZNeonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes10.1038/s41467-018-06423-72041-1723https://doaj.org/article/3d292c2802f1404fac2cc90eb9e52fbb2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06423-7https://doaj.org/toc/2041-1723Induction of tolerance in the gut relies on immunomodulatory functions of mesenteric lymph nodes (mLN). Here the authors show that mLN stromal cells receive early microbiota imprinting in the neonatal phase to exhibit long-term, location-specific transcriptional programs for the induction of regulatory T cells and peripheral tolerance.Joern PezoldtMaria PasztoiMangge ZouCarolin WiechersMichael BeckstetteGuilhem R. ThierryEhsan VafadarnejadStefan FloessPanagiota ArampatziManuela BuettnerJanina SchweerDiana FleissnerMarius VitalDietmar H. PieperMarijana BasicPetra DerschTill StrowigMathias HornefAndré BleichUlrike BodeOliver PabstMarc BajénoffAntoine-Emmanuel SalibaJochen HuehnNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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Science Q Joern Pezoldt Maria Pasztoi Mangge Zou Carolin Wiechers Michael Beckstette Guilhem R. Thierry Ehsan Vafadarnejad Stefan Floess Panagiota Arampatzi Manuela Buettner Janina Schweer Diana Fleissner Marius Vital Dietmar H. Pieper Marijana Basic Petra Dersch Till Strowig Mathias Hornef André Bleich Ulrike Bode Oliver Pabst Marc Bajénoff Antoine-Emmanuel Saliba Jochen Huehn Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes |
| description |
Induction of tolerance in the gut relies on immunomodulatory functions of mesenteric lymph nodes (mLN). Here the authors show that mLN stromal cells receive early microbiota imprinting in the neonatal phase to exhibit long-term, location-specific transcriptional programs for the induction of regulatory T cells and peripheral tolerance. |
| format |
article |
| author |
Joern Pezoldt Maria Pasztoi Mangge Zou Carolin Wiechers Michael Beckstette Guilhem R. Thierry Ehsan Vafadarnejad Stefan Floess Panagiota Arampatzi Manuela Buettner Janina Schweer Diana Fleissner Marius Vital Dietmar H. Pieper Marijana Basic Petra Dersch Till Strowig Mathias Hornef André Bleich Ulrike Bode Oliver Pabst Marc Bajénoff Antoine-Emmanuel Saliba Jochen Huehn |
| author_facet |
Joern Pezoldt Maria Pasztoi Mangge Zou Carolin Wiechers Michael Beckstette Guilhem R. Thierry Ehsan Vafadarnejad Stefan Floess Panagiota Arampatzi Manuela Buettner Janina Schweer Diana Fleissner Marius Vital Dietmar H. Pieper Marijana Basic Petra Dersch Till Strowig Mathias Hornef André Bleich Ulrike Bode Oliver Pabst Marc Bajénoff Antoine-Emmanuel Saliba Jochen Huehn |
| author_sort |
Joern Pezoldt |
| title |
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes |
| title_short |
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes |
| title_full |
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes |
| title_fullStr |
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes |
| title_full_unstemmed |
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes |
| title_sort |
neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/3d292c2802f1404fac2cc90eb9e52fbb |
| work_keys_str_mv |
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1718383093016952832 |