ARTS mediates apoptosis and regeneration of the intestinal stem cell niche

The mechanisms regulating intestinal stem cell elimination remain unclear. Here, the authors identify that the pro-apoptotic protein ARTS (a Septin4 isoform) interacts with XIAP in the intestinal stem cell niche to regulate stem cell survival during intestinal homeostasis and regeneration.

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Autores principales:	Elle Koren, Yahav Yosefzon, Roi Ankawa, Despina Soteriou, Avi Jacob, Alexander Nevelsky, Rahamim Ben-Yosef, Gil Bar-Sela, Yaron Fuchs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d2bd9fa6b9944f6b5e42563b3ccacf7
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spelling	oai:doaj.org-article:3d2bd9fa6b9944f6b5e42563b3ccacf72021-12-02T14:40:05ZARTS mediates apoptosis and regeneration of the intestinal stem cell niche10.1038/s41467-018-06941-42041-1723https://doaj.org/article/3d2bd9fa6b9944f6b5e42563b3ccacf72018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06941-4https://doaj.org/toc/2041-1723The mechanisms regulating intestinal stem cell elimination remain unclear. Here, the authors identify that the pro-apoptotic protein ARTS (a Septin4 isoform) interacts with XIAP in the intestinal stem cell niche to regulate stem cell survival during intestinal homeostasis and regeneration.Elle KorenYahav YosefzonRoi AnkawaDespina SoteriouAvi JacobAlexander NevelskyRahamim Ben-YosefGil Bar-SelaYaron FuchsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elle Koren Yahav Yosefzon Roi Ankawa Despina Soteriou Avi Jacob Alexander Nevelsky Rahamim Ben-Yosef Gil Bar-Sela Yaron Fuchs ARTS mediates apoptosis and regeneration of the intestinal stem cell niche
description	The mechanisms regulating intestinal stem cell elimination remain unclear. Here, the authors identify that the pro-apoptotic protein ARTS (a Septin4 isoform) interacts with XIAP in the intestinal stem cell niche to regulate stem cell survival during intestinal homeostasis and regeneration.
format	article
author	Elle Koren Yahav Yosefzon Roi Ankawa Despina Soteriou Avi Jacob Alexander Nevelsky Rahamim Ben-Yosef Gil Bar-Sela Yaron Fuchs
author_facet	Elle Koren Yahav Yosefzon Roi Ankawa Despina Soteriou Avi Jacob Alexander Nevelsky Rahamim Ben-Yosef Gil Bar-Sela Yaron Fuchs
author_sort	Elle Koren
title	ARTS mediates apoptosis and regeneration of the intestinal stem cell niche
title_short	ARTS mediates apoptosis and regeneration of the intestinal stem cell niche
title_full	ARTS mediates apoptosis and regeneration of the intestinal stem cell niche
title_fullStr	ARTS mediates apoptosis and regeneration of the intestinal stem cell niche
title_full_unstemmed	ARTS mediates apoptosis and regeneration of the intestinal stem cell niche
title_sort	arts mediates apoptosis and regeneration of the intestinal stem cell niche
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3d2bd9fa6b9944f6b5e42563b3ccacf7
work_keys_str_mv	AT ellekoren artsmediatesapoptosisandregenerationoftheintestinalstemcellniche AT yahavyosefzon artsmediatesapoptosisandregenerationoftheintestinalstemcellniche AT roiankawa artsmediatesapoptosisandregenerationoftheintestinalstemcellniche AT despinasoteriou artsmediatesapoptosisandregenerationoftheintestinalstemcellniche AT avijacob artsmediatesapoptosisandregenerationoftheintestinalstemcellniche AT alexandernevelsky artsmediatesapoptosisandregenerationoftheintestinalstemcellniche AT rahamimbenyosef artsmediatesapoptosisandregenerationoftheintestinalstemcellniche AT gilbarsela artsmediatesapoptosisandregenerationoftheintestinalstemcellniche AT yaronfuchs artsmediatesapoptosisandregenerationoftheintestinalstemcellniche
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ARTS mediates apoptosis and regeneration of the intestinal stem cell niche

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