Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties

Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to the high-molecular-mass hyaluronan produced by t...

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Autores principales: Masaki Takasugi, Denis Firsanov, Gregory Tombline, Hanbing Ning, Julia Ablaeva, Andrei Seluanov, Vera Gorbunova
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3d2c9477f013493bbf1623f28f0b5ae3
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Sumario:Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to the high-molecular-mass hyaluronan produced by these species.