Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties

Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties

Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to the high-molecular-mass hyaluronan produced by t...

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Autores principales: Masaki Takasugi, Denis Firsanov, Gregory Tombline, Hanbing Ning, Julia Ablaeva, Andrei Seluanov, Vera Gorbunova
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3d2c9477f013493bbf1623f28f0b5ae3
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spelling oai:doaj.org-article:3d2c9477f013493bbf1623f28f0b5ae32021-12-02T15:54:45ZNaked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties10.1038/s41467-020-16050-w2041-1723https://doaj.org/article/3d2c9477f013493bbf1623f28f0b5ae32020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16050-whttps://doaj.org/toc/2041-1723Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to the high-molecular-mass hyaluronan produced by these species.Masaki TakasugiDenis FirsanovGregory TomblineHanbing NingJulia AblaevaAndrei SeluanovVera GorbunovaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Masaki Takasugi
Denis Firsanov
Gregory Tombline
Hanbing Ning
Julia Ablaeva
Andrei Seluanov
Vera Gorbunova
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
description Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to the high-molecular-mass hyaluronan produced by these species.
format article
author Masaki Takasugi
Denis Firsanov
Gregory Tombline
Hanbing Ning
Julia Ablaeva
Andrei Seluanov
Vera Gorbunova
author_facet Masaki Takasugi
Denis Firsanov
Gregory Tombline
Hanbing Ning
Julia Ablaeva
Andrei Seluanov
Vera Gorbunova
author_sort Masaki Takasugi
title Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
title_short Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
title_full Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
title_fullStr Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
title_full_unstemmed Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
title_sort naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/3d2c9477f013493bbf1623f28f0b5ae3
work_keys_str_mv AT masakitakasugi nakedmoleratveryhighmolecularmasshyaluronanexhibitssuperiorcytoprotectiveproperties
AT denisfirsanov nakedmoleratveryhighmolecularmasshyaluronanexhibitssuperiorcytoprotectiveproperties
AT gregorytombline nakedmoleratveryhighmolecularmasshyaluronanexhibitssuperiorcytoprotectiveproperties
AT hanbingning nakedmoleratveryhighmolecularmasshyaluronanexhibitssuperiorcytoprotectiveproperties
AT juliaablaeva nakedmoleratveryhighmolecularmasshyaluronanexhibitssuperiorcytoprotectiveproperties
AT andreiseluanov nakedmoleratveryhighmolecularmasshyaluronanexhibitssuperiorcytoprotectiveproperties
AT veragorbunova nakedmoleratveryhighmolecularmasshyaluronanexhibitssuperiorcytoprotectiveproperties
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