Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A

Shubhra Chaturvedi,1 Sangeeta Lal,2 Prasenjit Sen,3 Anil K Mishra1 1Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, New Delhi, Delhi, 2Department of Physics, B.S. College, Magadh University, Patna, Bihar, 3School of Physical Sciences, Jawah...

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Autores principales:	Chaturvedi S, Lal S, Sen P, Mishra AK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Receptor Imaging Optical Imaging Targeted Nanoparticles. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3d2dc69cf6764a598ec8812db10943da
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spelling	oai:doaj.org-article:3d2dc69cf6764a598ec8812db10943da2021-12-02T04:21:41ZSynthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A1178-2013https://doaj.org/article/3d2dc69cf6764a598ec8812db10943da2018-03-01T00:00:00Zhttps://www.dovepress.com/synthesis-docking-and-preliminary-in-vitroin-vivo-evaluation-of-mpp-di-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shubhra Chaturvedi,1 Sangeeta Lal,2 Prasenjit Sen,3 Anil K Mishra1 1Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, New Delhi, Delhi, 2Department of Physics, B.S. College, Magadh University, Patna, Bihar, 3School of Physical Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India Abstract: Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT1A receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection limits. Our results demonstrate an easy synthesis of the ligand methoxyphenyl piperazine-dithiocarbamate and silver nanoparticles and their conjugation was free from extraneous impurities. Keywords: receptor imaging, optical imaging, targeted nanoparticlesChaturvedi SLal SSen PMishra AKDove Medical PressarticleReceptor ImagingOptical ImagingTargeted Nanoparticles.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 19-23 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Receptor Imaging Optical Imaging Targeted Nanoparticles. Medicine (General) R5-920
spellingShingle	Receptor Imaging Optical Imaging Targeted Nanoparticles. Medicine (General) R5-920 Chaturvedi S Lal S Sen P Mishra AK Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A
description	Shubhra Chaturvedi,1 Sangeeta Lal,2 Prasenjit Sen,3 Anil K Mishra1 1Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, New Delhi, Delhi, 2Department of Physics, B.S. College, Magadh University, Patna, Bihar, 3School of Physical Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India Abstract: Methoxyphenyl piperazine is a versatile pharmacophore and has been exploited for targeting 5HT1A receptors. In the present study, silver nanoparticles were conjugated (capped) with methoxyphenyl piperazine-dithiocarbamate for application as targeted optical imaging agent at extremely low detection limits. Our results demonstrate an easy synthesis of the ligand methoxyphenyl piperazine-dithiocarbamate and silver nanoparticles and their conjugation was free from extraneous impurities. Keywords: receptor imaging, optical imaging, targeted nanoparticles
format	article
author	Chaturvedi S Lal S Sen P Mishra AK
author_facet	Chaturvedi S Lal S Sen P Mishra AK
author_sort	Chaturvedi S
title	Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A
title_short	Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A
title_full	Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A
title_fullStr	Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A
title_full_unstemmed	Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A
title_sort	synthesis, docking, and preliminary in vitro/in vivo evaluation of mpp-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5ht1a
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3d2dc69cf6764a598ec8812db10943da
work_keys_str_mv	AT chaturvedis synthesisdockingandpreliminaryinvitroinvivoevaluationofmppdithiocarbamatecappedsilvernanoparticleasdualimagingagentfor5ht1a AT lals synthesisdockingandpreliminaryinvitroinvivoevaluationofmppdithiocarbamatecappedsilvernanoparticleasdualimagingagentfor5ht1a AT senp synthesisdockingandpreliminaryinvitroinvivoevaluationofmppdithiocarbamatecappedsilvernanoparticleasdualimagingagentfor5ht1a AT mishraak synthesisdockingandpreliminaryinvitroinvivoevaluationofmppdithiocarbamatecappedsilvernanoparticleasdualimagingagentfor5ht1a
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Synthesis, docking, and preliminary in vitro/in vivo evaluation of MPP-dithiocarbamate-capped silver nanoparticle as dual-imaging agent for 5HT1A

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