A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells

Futrega et al. challenge the long established chondrogenic differentiation protocol used to induce bone marrow-derived stromal cell (BMSC) differentiation which presumes the need for more than 2 weeks of continuous TGF-β1 exposure. Using a micro-pellet model, they show that BMSC differentiation is t...

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Autores principales:	Kathryn Futrega, Pamela G. Robey, Travis J. Klein, Ross W. Crawford, Michael R. Doran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3d2fae483ee04c689e0ddf9c60a6d72c
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spelling	oai:doaj.org-article:3d2fae483ee04c689e0ddf9c60a6d72c2021-12-02T11:56:22ZA single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells10.1038/s42003-020-01520-02399-3642https://doaj.org/article/3d2fae483ee04c689e0ddf9c60a6d72c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01520-0https://doaj.org/toc/2399-3642Futrega et al. challenge the long established chondrogenic differentiation protocol used to induce bone marrow-derived stromal cell (BMSC) differentiation which presumes the need for more than 2 weeks of continuous TGF-β1 exposure. Using a micro-pellet model, they show that BMSC differentiation is triggered by a single day of TGF-β1 exposure.Kathryn FutregaPamela G. RobeyTravis J. KleinRoss W. CrawfordMichael R. DoranNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kathryn Futrega Pamela G. Robey Travis J. Klein Ross W. Crawford Michael R. Doran A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
description	Futrega et al. challenge the long established chondrogenic differentiation protocol used to induce bone marrow-derived stromal cell (BMSC) differentiation which presumes the need for more than 2 weeks of continuous TGF-β1 exposure. Using a micro-pellet model, they show that BMSC differentiation is triggered by a single day of TGF-β1 exposure.
format	article
author	Kathryn Futrega Pamela G. Robey Travis J. Klein Ross W. Crawford Michael R. Doran
author_facet	Kathryn Futrega Pamela G. Robey Travis J. Klein Ross W. Crawford Michael R. Doran
author_sort	Kathryn Futrega
title	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_short	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_full	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_fullStr	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_full_unstemmed	A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
title_sort	single day of tgf-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d2fae483ee04c689e0ddf9c60a6d72c
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A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells

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