The energy cost of polypeptide knot formation and its folding consequences

The effect of knots on protein stability and folding kinetics is not well understood. Here the authors combine optical tweezer experiments and calculations to experimentally determine the energy cost for knot formation, which indicates that knotted proteins evolved specific folding pathways because...

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Autores principales: Andrés Bustamante, Juan Sotelo-Campos, Daniel G. Guerra, Martin Floor, Christian A. M. Wilson, Carlos Bustamante, Mauricio Báez
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3d303fa72ca546338630c764cd74af4c
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