Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepatitis B vaccination in healthy, elderly adults.

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Autores principales:	Slim Fourati, Razvan Cristescu, Andrey Loboda, Aarthi Talla, Ali Filali, Radha Railkar, Andrea K. Schaeffer, David Favre, Dominic Gagnon, Yoav Peretz, I-Ming Wang, Chan R. Beals, Danilo R. Casimiro, Leonidas N. Carayannopoulos, Rafick-Pierre Sékaly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d312c5aa0404caa898a6b2a5c38fdde
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spelling	oai:doaj.org-article:3d312c5aa0404caa898a6b2a5c38fdde2021-12-02T16:49:25ZPre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination10.1038/ncomms103692041-1723https://doaj.org/article/3d312c5aa0404caa898a6b2a5c38fdde2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10369https://doaj.org/toc/2041-1723Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepatitis B vaccination in healthy, elderly adults.Slim FouratiRazvan CristescuAndrey LobodaAarthi TallaAli FilaliRadha RailkarAndrea K. SchaefferDavid FavreDominic GagnonYoav PeretzI-Ming WangChan R. BealsDanilo R. CasimiroLeonidas N. CarayannopoulosRafick-Pierre SékalyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Slim Fourati Razvan Cristescu Andrey Loboda Aarthi Talla Ali Filali Radha Railkar Andrea K. Schaeffer David Favre Dominic Gagnon Yoav Peretz I-Ming Wang Chan R. Beals Danilo R. Casimiro Leonidas N. Carayannopoulos Rafick-Pierre Sékaly Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination
description	Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepatitis B vaccination in healthy, elderly adults.
format	article
author	Slim Fourati Razvan Cristescu Andrey Loboda Aarthi Talla Ali Filali Radha Railkar Andrea K. Schaeffer David Favre Dominic Gagnon Yoav Peretz I-Ming Wang Chan R. Beals Danilo R. Casimiro Leonidas N. Carayannopoulos Rafick-Pierre Sékaly
author_facet	Slim Fourati Razvan Cristescu Andrey Loboda Aarthi Talla Ali Filali Radha Railkar Andrea K. Schaeffer David Favre Dominic Gagnon Yoav Peretz I-Ming Wang Chan R. Beals Danilo R. Casimiro Leonidas N. Carayannopoulos Rafick-Pierre Sékaly
author_sort	Slim Fourati
title	Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination
title_short	Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination
title_full	Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination
title_fullStr	Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination
title_full_unstemmed	Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination
title_sort	pre-vaccination inflammation and b-cell signalling predict age-related hyporesponse to hepatitis b vaccination
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3d312c5aa0404caa898a6b2a5c38fdde
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Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

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