Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepatitis B vaccination in healthy, elderly adults.

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Bibliographic Details
Main Authors: Slim Fourati, Razvan Cristescu, Andrey Loboda, Aarthi Talla, Ali Filali, Radha Railkar, Andrea K. Schaeffer, David Favre, Dominic Gagnon, Yoav Peretz, I-Ming Wang, Chan R. Beals, Danilo R. Casimiro, Leonidas N. Carayannopoulos, Rafick-Pierre Sékaly
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/3d312c5aa0404caa898a6b2a5c38fdde
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https://doaj.org/article/3d312c5aa0404caa898a6b2a5c38fdde

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