Effects of intermolecular interactions on the stability of carbon nanotube–gold nanoparticle conjugates in solution
Lukasz Konczak,1 Jolanta Narkiewicz-Michalek,2 Giorgia Pastorin,3 Tomasz Panczyk1 1Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Cracow, 2Department of Chemistry, Maria Curie-Sklodowska University, Lublin, Poland; 3Department of Pharmacy, National University of Singapore...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/3d32238b9c454c6db9d366bbff8b1cc3 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:3d32238b9c454c6db9d366bbff8b1cc3 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:3d32238b9c454c6db9d366bbff8b1cc32021-12-02T05:02:52ZEffects of intermolecular interactions on the stability of carbon nanotube–gold nanoparticle conjugates in solution1178-2013https://doaj.org/article/3d32238b9c454c6db9d366bbff8b1cc32016-11-01T00:00:00Zhttps://www.dovepress.com/effects-of-intermolecular-interactions-on-the-stability-of-carbon-nano-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Lukasz Konczak,1 Jolanta Narkiewicz-Michalek,2 Giorgia Pastorin,3 Tomasz Panczyk1 1Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Cracow, 2Department of Chemistry, Maria Curie-Sklodowska University, Lublin, Poland; 3Department of Pharmacy, National University of Singapore, Singapore Abstract: This work deals with the role of intermolecular interactions in the stability of a carbon nanotube (CNT) capped by functionalized gold nanoparticles (AuNPs). The importance of such a system is due to its potential application as a pH-controlled drug carrier. Our preliminary experimental studies showed that fabrication of such a nanobottle/nanocontainer is feasible and it is possible to encapsulate the anticancer drug cisplatin inside the inner space of a CNT and seal its ends by functionalized AuNPs. The expected behavior, that is, detachment of AuNPs at acidic pH and the release of cisplatin, was, however, not observed. On the other hand, our theoretical studies of chemically identical system led to the conclusion that the release of cisplatin at acidic pH should be observed. Therefore, in this work, a deeper theoretical analysis of various factors that could be responsible for the disagreement between experimental and theoretical results were performed. The study found that the major factor is a large dispersion interaction component acting between CNT and AuNP in solution in the case of the experimental system. This factor can be controlled to some extent by tuning the system size or the ratio between AuNP diameter and CNT diameter. Thus, such kind of a pH-sensitive drug carrier is still of great interest, but its structural parameters need to be properly adjusted. Keywords: hydrazone bond, drug delivery, dispersion interactions, cisplatin, acidic pHKonczak LNarkiewicz-Michalek JPastorin GPanczyk TDove Medical Pressarticlecarbon nanotubedrug deliverypH responsivecisplatingold nanoparticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 5837-5849 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
carbon nanotube drug delivery pH responsive cisplatin gold nanoparticle Medicine (General) R5-920 |
| spellingShingle |
carbon nanotube drug delivery pH responsive cisplatin gold nanoparticle Medicine (General) R5-920 Konczak L Narkiewicz-Michalek J Pastorin G Panczyk T Effects of intermolecular interactions on the stability of carbon nanotube–gold nanoparticle conjugates in solution |
| description |
Lukasz Konczak,1 Jolanta Narkiewicz-Michalek,2 Giorgia Pastorin,3 Tomasz Panczyk1 1Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Cracow, 2Department of Chemistry, Maria Curie-Sklodowska University, Lublin, Poland; 3Department of Pharmacy, National University of Singapore, Singapore Abstract: This work deals with the role of intermolecular interactions in the stability of a carbon nanotube (CNT) capped by functionalized gold nanoparticles (AuNPs). The importance of such a system is due to its potential application as a pH-controlled drug carrier. Our preliminary experimental studies showed that fabrication of such a nanobottle/nanocontainer is feasible and it is possible to encapsulate the anticancer drug cisplatin inside the inner space of a CNT and seal its ends by functionalized AuNPs. The expected behavior, that is, detachment of AuNPs at acidic pH and the release of cisplatin, was, however, not observed. On the other hand, our theoretical studies of chemically identical system led to the conclusion that the release of cisplatin at acidic pH should be observed. Therefore, in this work, a deeper theoretical analysis of various factors that could be responsible for the disagreement between experimental and theoretical results were performed. The study found that the major factor is a large dispersion interaction component acting between CNT and AuNP in solution in the case of the experimental system. This factor can be controlled to some extent by tuning the system size or the ratio between AuNP diameter and CNT diameter. Thus, such kind of a pH-sensitive drug carrier is still of great interest, but its structural parameters need to be properly adjusted. Keywords: hydrazone bond, drug delivery, dispersion interactions, cisplatin, acidic pH |
| format |
article |
| author |
Konczak L Narkiewicz-Michalek J Pastorin G Panczyk T |
| author_facet |
Konczak L Narkiewicz-Michalek J Pastorin G Panczyk T |
| author_sort |
Konczak L |
| title |
Effects of intermolecular interactions on the stability of carbon nanotube–gold nanoparticle conjugates in solution |
| title_short |
Effects of intermolecular interactions on the stability of carbon nanotube–gold nanoparticle conjugates in solution |
| title_full |
Effects of intermolecular interactions on the stability of carbon nanotube–gold nanoparticle conjugates in solution |
| title_fullStr |
Effects of intermolecular interactions on the stability of carbon nanotube–gold nanoparticle conjugates in solution |
| title_full_unstemmed |
Effects of intermolecular interactions on the stability of carbon nanotube–gold nanoparticle conjugates in solution |
| title_sort |
effects of intermolecular interactions on the stability of carbon nanotube–gold nanoparticle conjugates in solution |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/3d32238b9c454c6db9d366bbff8b1cc3 |
| work_keys_str_mv |
AT konczakl effectsofintermolecularinteractionsonthestabilityofcarbonnanotubendashgoldnanoparticleconjugatesinsolution AT narkiewiczmichalekj effectsofintermolecularinteractionsonthestabilityofcarbonnanotubendashgoldnanoparticleconjugatesinsolution AT pastoring effectsofintermolecularinteractionsonthestabilityofcarbonnanotubendashgoldnanoparticleconjugatesinsolution AT panczykt effectsofintermolecularinteractionsonthestabilityofcarbonnanotubendashgoldnanoparticleconjugatesinsolution |
| _version_ |
1718400704291274752 |