Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development

Abstract All motile organisms need to organize their motor output to obtain functional goals. In vertebrates, natural behaviors are generally composed of a relatively large set of motor components which in turn are combined into a rich repertoire of complex actions. It is therefore an experimental c...

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Autores principales:	Tobias Palmér, Fredrik Ek, Olof Enqvist, Roger Olsson, Kalle Åström, Per Petersson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d3384e576544f5a831803b6b189b1a9
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spelling	oai:doaj.org-article:3d3384e576544f5a831803b6b189b1a92021-12-02T11:52:31ZAction sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development10.1038/s41598-017-03144-72045-2322https://doaj.org/article/3d3384e576544f5a831803b6b189b1a92017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03144-7https://doaj.org/toc/2045-2322Abstract All motile organisms need to organize their motor output to obtain functional goals. In vertebrates, natural behaviors are generally composed of a relatively large set of motor components which in turn are combined into a rich repertoire of complex actions. It is therefore an experimental challenge to investigate the organizational principles of natural behaviors. Using the relatively simple locomotion pattern of 10 days old zebrafish larvae we have here characterized the basic organizational principles governing the swimming behavior. Our results show that transitions between different behavioral states can be described by a model combining a stochastic component with a control signal. By dividing swimming bouts into a limited number of categories, we show that similar types of swimming behavior as well as stand-stills between bouts were temporally clustered, indicating a basic level of action sequencing. Finally, we show that pharmacological manipulations known to induce alterations in the organization of motor behavior in mammals, mainly through basal ganglia interactions, have related effects in zebrafish larvae. This latter finding may be of specific relevance to the field of drug development given the growing importance of zebrafish larvae in phenotypic screening for novel drug candidates acting on central nervous system targets.Tobias PalmérFredrik EkOlof EnqvistRoger OlssonKalle ÅströmPer PeterssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tobias Palmér Fredrik Ek Olof Enqvist Roger Olsson Kalle Åström Per Petersson Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development
description	Abstract All motile organisms need to organize their motor output to obtain functional goals. In vertebrates, natural behaviors are generally composed of a relatively large set of motor components which in turn are combined into a rich repertoire of complex actions. It is therefore an experimental challenge to investigate the organizational principles of natural behaviors. Using the relatively simple locomotion pattern of 10 days old zebrafish larvae we have here characterized the basic organizational principles governing the swimming behavior. Our results show that transitions between different behavioral states can be described by a model combining a stochastic component with a control signal. By dividing swimming bouts into a limited number of categories, we show that similar types of swimming behavior as well as stand-stills between bouts were temporally clustered, indicating a basic level of action sequencing. Finally, we show that pharmacological manipulations known to induce alterations in the organization of motor behavior in mammals, mainly through basal ganglia interactions, have related effects in zebrafish larvae. This latter finding may be of specific relevance to the field of drug development given the growing importance of zebrafish larvae in phenotypic screening for novel drug candidates acting on central nervous system targets.
format	article
author	Tobias Palmér Fredrik Ek Olof Enqvist Roger Olsson Kalle Åström Per Petersson
author_facet	Tobias Palmér Fredrik Ek Olof Enqvist Roger Olsson Kalle Åström Per Petersson
author_sort	Tobias Palmér
title	Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development
title_short	Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development
title_full	Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development
title_fullStr	Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development
title_full_unstemmed	Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development
title_sort	action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3d3384e576544f5a831803b6b189b1a9
work_keys_str_mv	AT tobiaspalmer actionsequencinginthespontaneousswimmingbehaviorofzebrafishlarvaeimplicationsfordrugdevelopment AT fredrikek actionsequencinginthespontaneousswimmingbehaviorofzebrafishlarvaeimplicationsfordrugdevelopment AT olofenqvist actionsequencinginthespontaneousswimmingbehaviorofzebrafishlarvaeimplicationsfordrugdevelopment AT rogerolsson actionsequencinginthespontaneousswimmingbehaviorofzebrafishlarvaeimplicationsfordrugdevelopment AT kalleastrom actionsequencinginthespontaneousswimmingbehaviorofzebrafishlarvaeimplicationsfordrugdevelopment AT perpetersson actionsequencinginthespontaneousswimmingbehaviorofzebrafishlarvaeimplicationsfordrugdevelopment
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Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development

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