Minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children

Abstract Ultrasound-guided axillary brachial plexus block is increasingly used in preschool-age patients. However, the minimum effective volume of local anaesthetics has not been determined. With ethical committee approval and written informed consent from the guardians of all paediatric patients, w...

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Autores principales:	Liang Chen, Yang Shen, Shuangmei Liu, Yanyan Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d344eaaf480420c872fc00cb79211d0
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spelling	oai:doaj.org-article:3d344eaaf480420c872fc00cb79211d02021-12-02T16:45:47ZMinimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children10.1038/s41598-021-96582-32045-2322https://doaj.org/article/3d344eaaf480420c872fc00cb79211d02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96582-3https://doaj.org/toc/2045-2322Abstract Ultrasound-guided axillary brachial plexus block is increasingly used in preschool-age patients. However, the minimum effective volume of local anaesthetics has not been determined. With ethical committee approval and written informed consent from the guardians of all paediatric patients, we studied 27 consecutive patients aged 3 to 6 years who were scheduled for hand surgery. After general anaesthesia, eligible patients received a set volume of ultrasound-guided axillary brachial plexus block. We determined the volume of 0.2% ropivacaine for consecutive patients from the preceding patient’s outcome. The initial volume was 0.4 ml/kg. The testing interval was set at 0.05 ml/kg, and the lowest volume was 0.1 ml/kg. The following conditions were defined as a successful block: no heart rate changes, body movement, or ventilatory disorders during the operation; no use of fentanyl in the PACU; and a postoperative sensory block score < 3. The sequences of positive and negative blocks in consecutive patients were recorded. Using probit regression analysis, the 50% effective volume was 0.185 ml/kg (95% CI 0.123–0.234), and the 95% effective volume was 0.280 ml/kg (95% CI 0.232–0.593). EV50 and EV95 values of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block were 0.185 ml/kg and 0.280 ml/kg, respectively.Liang ChenYang ShenShuangmei LiuYanyan CaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang Chen Yang Shen Shuangmei Liu Yanyan Cao Minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children
description	Abstract Ultrasound-guided axillary brachial plexus block is increasingly used in preschool-age patients. However, the minimum effective volume of local anaesthetics has not been determined. With ethical committee approval and written informed consent from the guardians of all paediatric patients, we studied 27 consecutive patients aged 3 to 6 years who were scheduled for hand surgery. After general anaesthesia, eligible patients received a set volume of ultrasound-guided axillary brachial plexus block. We determined the volume of 0.2% ropivacaine for consecutive patients from the preceding patient’s outcome. The initial volume was 0.4 ml/kg. The testing interval was set at 0.05 ml/kg, and the lowest volume was 0.1 ml/kg. The following conditions were defined as a successful block: no heart rate changes, body movement, or ventilatory disorders during the operation; no use of fentanyl in the PACU; and a postoperative sensory block score < 3. The sequences of positive and negative blocks in consecutive patients were recorded. Using probit regression analysis, the 50% effective volume was 0.185 ml/kg (95% CI 0.123–0.234), and the 95% effective volume was 0.280 ml/kg (95% CI 0.232–0.593). EV50 and EV95 values of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block were 0.185 ml/kg and 0.280 ml/kg, respectively.
format	article
author	Liang Chen Yang Shen Shuangmei Liu Yanyan Cao
author_facet	Liang Chen Yang Shen Shuangmei Liu Yanyan Cao
author_sort	Liang Chen
title	Minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children
title_short	Minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children
title_full	Minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children
title_fullStr	Minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children
title_full_unstemmed	Minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children
title_sort	minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d344eaaf480420c872fc00cb79211d0
work_keys_str_mv	AT liangchen minimumeffectivevolumeof02ropivacaineforultrasoundguidedaxillarybrachialplexusblockinpreschoolagechildren AT yangshen minimumeffectivevolumeof02ropivacaineforultrasoundguidedaxillarybrachialplexusblockinpreschoolagechildren AT shuangmeiliu minimumeffectivevolumeof02ropivacaineforultrasoundguidedaxillarybrachialplexusblockinpreschoolagechildren AT yanyancao minimumeffectivevolumeof02ropivacaineforultrasoundguidedaxillarybrachialplexusblockinpreschoolagechildren
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Minimum effective volume of 0.2% ropivacaine for ultrasound-guided axillary brachial plexus block in preschool-age children

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