INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET

Molecular basis still remains unclear for psoriasis, a chronic inflammatory skin disease. It biological features are presented by abnormal differentiation of epidermal keratinocytes, overgrowth and dilation of blood vessels, and leukocyte infiltration of dermal and epidermal skin layers. These event...

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Autores principales:	E. S. Galimova, E. K. Khusnutdinova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	genetic association psoriasis interferon lambda genes ifnλr1 il28ra gene Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3d3628fbf40344fd91270c24b8e12267
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spelling	oai:doaj.org-article:3d3628fbf40344fd91270c24b8e122672021-11-18T08:03:45ZINTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET1563-06252313-741X10.15789/1563-0625-2015-6-567-572https://doaj.org/article/3d3628fbf40344fd91270c24b8e122672016-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/964https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMolecular basis still remains unclear for psoriasis, a chronic inflammatory skin disease. It biological features are presented by abnormal differentiation of epidermal keratinocytes, overgrowth and dilation of blood vessels, and leukocyte infiltration of dermal and epidermal skin layers. These events appear to be driven, mainly, by various cytokines and chemokines released by activated T cell populations. The aim of this replication study was to determine, whether the rs4649203 SNP of IL28RA gene is associated with susceptibility to psoriasis. A total of 341 patients with psoriasis and 407 matched healthy controls were enrolled to carry out a case control study. Genotyping was performed using a Real-Time PCR assay. Our preliminary data suggest that the polymorphism located in IL28RA gene, known to be related to inflammatory and immunity processes, showed an association with patients’ age at onset and the disease severity. The results of this study are promising, with respect to development of a personalized approach to psoriasis treatment.E. S. GalimovaE. K. KhusnutdinovaSPb RAACIarticlegenetic associationpsoriasisinterferon lambda genesifnλr1il28ra geneImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 6, Pp 567-572 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	genetic association psoriasis interferon lambda genes ifnλr1 il28ra gene Immunologic diseases. Allergy RC581-607
spellingShingle	genetic association psoriasis interferon lambda genes ifnλr1 il28ra gene Immunologic diseases. Allergy RC581-607 E. S. Galimova E. K. Khusnutdinova INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET
description	Molecular basis still remains unclear for psoriasis, a chronic inflammatory skin disease. It biological features are presented by abnormal differentiation of epidermal keratinocytes, overgrowth and dilation of blood vessels, and leukocyte infiltration of dermal and epidermal skin layers. These events appear to be driven, mainly, by various cytokines and chemokines released by activated T cell populations. The aim of this replication study was to determine, whether the rs4649203 SNP of IL28RA gene is associated with susceptibility to psoriasis. A total of 341 patients with psoriasis and 407 matched healthy controls were enrolled to carry out a case control study. Genotyping was performed using a Real-Time PCR assay. Our preliminary data suggest that the polymorphism located in IL28RA gene, known to be related to inflammatory and immunity processes, showed an association with patients’ age at onset and the disease severity. The results of this study are promising, with respect to development of a personalized approach to psoriasis treatment.
format	article
author	E. S. Galimova E. K. Khusnutdinova
author_facet	E. S. Galimova E. K. Khusnutdinova
author_sort	E. S. Galimova
title	INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET
title_short	INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET
title_full	INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET
title_fullStr	INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET
title_full_unstemmed	INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET
title_sort	interleukin 28 receptor gene alpha il28ra and psoriasis: association with disease severity and age at onset
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/3d3628fbf40344fd91270c24b8e12267
work_keys_str_mv	AT esgalimova interleukin28receptorgenealphail28raandpsoriasisassociationwithdiseaseseverityandageatonset AT ekkhusnutdinova interleukin28receptorgenealphail28raandpsoriasisassociationwithdiseaseseverityandageatonset
_version_	1718422411361124352

INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET

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