Dual-Energy Lung Perfusion in Portal Venous Phase CT—A Comparison with the Pulmonary Arterial Phase

Pulmonary arterial dual-energy (aDE) CT is an established technique for evaluating pulmonary perfusion blood volume (PBV). As DECT protocols are increasingly used for thoraco-abdominal CT, this study assessed image quality and clinical findings in portal–venous phase dual-energy (vDE) CT and compare...

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Autores principales:	Isabelle Praël, Wolfgang Wuest, Rafael Heiss, Marco Wiesmueller, Markus Kopp, Michael Uder, Matthias S. May
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dual-energy computed tomography lung perfusion portal venous Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3d3733d7f4c6403887700d00c5d4f233
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spelling	oai:doaj.org-article:3d3733d7f4c6403887700d00c5d4f2332021-11-25T17:20:32ZDual-Energy Lung Perfusion in Portal Venous Phase CT—A Comparison with the Pulmonary Arterial Phase10.3390/diagnostics111119892075-4418https://doaj.org/article/3d3733d7f4c6403887700d00c5d4f2332021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1989https://doaj.org/toc/2075-4418Pulmonary arterial dual-energy (aDE) CT is an established technique for evaluating pulmonary perfusion blood volume (PBV). As DECT protocols are increasingly used for thoraco-abdominal CT, this study assessed image quality and clinical findings in portal–venous phase dual-energy (vDE) CT and compared it to aDE. In 95 patients, vDE-CT was performed using a dual-source scanner (70/Sn150 kV, 560/140 ref.mAs). Pulmonary triggered aDE-CT served as reference (<i>n</i> = 94). PBV was reconstructed using a dedicated algorithm. Mean relative attenuation was measured in the pulmonary trunk, aorta, and segmented lung parenchyma. A distribution ratio (DL) between vessels and parenchyma was calculated to assess the iodine uptake of the lung parenchyma. Subjective overall diagnostic image quality was assessed for PBV images on a five-point Likert scale. Image artifacts were classified into five groups based on scale rating and compared between vDE and aDE. Pathological findings were correlated with the anatomical image datasets. Mean relative attenuation of the lung parenchyma was comparable in both groups (vDE: 23 ± 6 HU and aDE: 22 ± 7 HU), but significantly lower in the vessels of vDE. Therefore, iodine uptake of the lung parenchyma was significantly higher in vDE (DL: 10% vs. 8%, <i>p</i> < 0.01). The subjective overall image quality of the PBV images was comparable (<i>p</i> = 0.5). Rotation and streak artifacts were found in most of the patients (>86%, both <i>p</i> > 0.6). Dual-source artifacts were found in only a few patients in both groups (vDE 5%, aDE 7%, <i>p</i> = 0.5). Recess and subpleural artifacts were increased in vDE (vDE 53/27%, aDE 24/7%, both <i>p</i> < 0.001). Pathological findings were found in 19% of the vDE patients and 59% of the aDE patients. Comparable objective and subjective image quality of lung perfusion can be obtained in vDE and aDE. Iodine uptake of the lung parenchyma is increased in vDE compared to aDE, suggesting an interstitial pooling effect. Knowledge of the different appearances of artifacts will aid in the interpretation of the images. Additional clinical information about the lung parenchyma can be provided by PBV evaluation in vDE.Isabelle PraëlWolfgang WuestRafael HeissMarco WiesmuellerMarkus KoppMichael UderMatthias S. MayMDPI AGarticledual-energy computed tomographylung perfusionportal venousMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1989, p 1989 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dual-energy computed tomography lung perfusion portal venous Medicine (General) R5-920
spellingShingle	dual-energy computed tomography lung perfusion portal venous Medicine (General) R5-920 Isabelle Praël Wolfgang Wuest Rafael Heiss Marco Wiesmueller Markus Kopp Michael Uder Matthias S. May Dual-Energy Lung Perfusion in Portal Venous Phase CT—A Comparison with the Pulmonary Arterial Phase
description	Pulmonary arterial dual-energy (aDE) CT is an established technique for evaluating pulmonary perfusion blood volume (PBV). As DECT protocols are increasingly used for thoraco-abdominal CT, this study assessed image quality and clinical findings in portal–venous phase dual-energy (vDE) CT and compared it to aDE. In 95 patients, vDE-CT was performed using a dual-source scanner (70/Sn150 kV, 560/140 ref.mAs). Pulmonary triggered aDE-CT served as reference (<i>n</i> = 94). PBV was reconstructed using a dedicated algorithm. Mean relative attenuation was measured in the pulmonary trunk, aorta, and segmented lung parenchyma. A distribution ratio (DL) between vessels and parenchyma was calculated to assess the iodine uptake of the lung parenchyma. Subjective overall diagnostic image quality was assessed for PBV images on a five-point Likert scale. Image artifacts were classified into five groups based on scale rating and compared between vDE and aDE. Pathological findings were correlated with the anatomical image datasets. Mean relative attenuation of the lung parenchyma was comparable in both groups (vDE: 23 ± 6 HU and aDE: 22 ± 7 HU), but significantly lower in the vessels of vDE. Therefore, iodine uptake of the lung parenchyma was significantly higher in vDE (DL: 10% vs. 8%, <i>p</i> < 0.01). The subjective overall image quality of the PBV images was comparable (<i>p</i> = 0.5). Rotation and streak artifacts were found in most of the patients (>86%, both <i>p</i> > 0.6). Dual-source artifacts were found in only a few patients in both groups (vDE 5%, aDE 7%, <i>p</i> = 0.5). Recess and subpleural artifacts were increased in vDE (vDE 53/27%, aDE 24/7%, both <i>p</i> < 0.001). Pathological findings were found in 19% of the vDE patients and 59% of the aDE patients. Comparable objective and subjective image quality of lung perfusion can be obtained in vDE and aDE. Iodine uptake of the lung parenchyma is increased in vDE compared to aDE, suggesting an interstitial pooling effect. Knowledge of the different appearances of artifacts will aid in the interpretation of the images. Additional clinical information about the lung parenchyma can be provided by PBV evaluation in vDE.
format	article
author	Isabelle Praël Wolfgang Wuest Rafael Heiss Marco Wiesmueller Markus Kopp Michael Uder Matthias S. May
author_facet	Isabelle Praël Wolfgang Wuest Rafael Heiss Marco Wiesmueller Markus Kopp Michael Uder Matthias S. May
author_sort	Isabelle Praël
title	Dual-Energy Lung Perfusion in Portal Venous Phase CT—A Comparison with the Pulmonary Arterial Phase
title_short	Dual-Energy Lung Perfusion in Portal Venous Phase CT—A Comparison with the Pulmonary Arterial Phase
title_full	Dual-Energy Lung Perfusion in Portal Venous Phase CT—A Comparison with the Pulmonary Arterial Phase
title_fullStr	Dual-Energy Lung Perfusion in Portal Venous Phase CT—A Comparison with the Pulmonary Arterial Phase
title_full_unstemmed	Dual-Energy Lung Perfusion in Portal Venous Phase CT—A Comparison with the Pulmonary Arterial Phase
title_sort	dual-energy lung perfusion in portal venous phase ct—a comparison with the pulmonary arterial phase
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3d3733d7f4c6403887700d00c5d4f233
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Dual-Energy Lung Perfusion in Portal Venous Phase CT—A Comparison with the Pulmonary Arterial Phase

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