Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

Chronic myelomonocytic leukaemia is treated with agents that modify DNA methylation but whether they have direct cytotoxic effects is unclear. Here, the authors show that cells from treated patients show marked methylation changes without altered somatic mutation burden, suggesting that cytotoxicity...

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Autores principales: Jane Merlevede, Nathalie Droin, Tingting Qin, Kristen Meldi, Kenichi Yoshida, Margot Morabito, Emilie Chautard, Didier Auboeuf, Pierre Fenaux, Thorsten Braun, Raphael Itzykson, Stéphane de Botton, Bruno Quesnel, Thérèse Commes, Eric Jourdan, William Vainchenker, Olivier Bernard, Noemie Pata-Merci, Stéphanie Solier, Velimir Gayevskiy, Marcel E. Dinger, Mark J. Cowley, Dorothée Selimoglu-Buet, Vincent Meyer, François Artiguenave, Jean-François Deleuze, Claude Preudhomme, Michael R. Stratton, Ludmil B. Alexandrov, Eric Padron, Seishi Ogawa, Serge Koscielny, Maria Figueroa, Eric Solary
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3d387d13bd0349019c8a2486e3d50c61
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spelling oai:doaj.org-article:3d387d13bd0349019c8a2486e3d50c612021-12-02T17:31:19ZMutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents10.1038/ncomms107672041-1723https://doaj.org/article/3d387d13bd0349019c8a2486e3d50c612016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10767https://doaj.org/toc/2041-1723Chronic myelomonocytic leukaemia is treated with agents that modify DNA methylation but whether they have direct cytotoxic effects is unclear. Here, the authors show that cells from treated patients show marked methylation changes without altered somatic mutation burden, suggesting that cytotoxicity is not a major factor in therapeutic efficacy.Jane MerlevedeNathalie DroinTingting QinKristen MeldiKenichi YoshidaMargot MorabitoEmilie ChautardDidier AuboeufPierre FenauxThorsten BraunRaphael ItzyksonStéphane de BottonBruno QuesnelThérèse CommesEric JourdanWilliam VainchenkerOlivier BernardNoemie Pata-MerciStéphanie SolierVelimir GayevskiyMarcel E. DingerMark J. CowleyDorothée Selimoglu-BuetVincent MeyerFrançois ArtiguenaveJean-François DeleuzeClaude PreudhommeMichael R. StrattonLudmil B. AlexandrovEric PadronSeishi OgawaSerge KoscielnyMaria FigueroaEric SolaryNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jane Merlevede
Nathalie Droin
Tingting Qin
Kristen Meldi
Kenichi Yoshida
Margot Morabito
Emilie Chautard
Didier Auboeuf
Pierre Fenaux
Thorsten Braun
Raphael Itzykson
Stéphane de Botton
Bruno Quesnel
Thérèse Commes
Eric Jourdan
William Vainchenker
Olivier Bernard
Noemie Pata-Merci
Stéphanie Solier
Velimir Gayevskiy
Marcel E. Dinger
Mark J. Cowley
Dorothée Selimoglu-Buet
Vincent Meyer
François Artiguenave
Jean-François Deleuze
Claude Preudhomme
Michael R. Stratton
Ludmil B. Alexandrov
Eric Padron
Seishi Ogawa
Serge Koscielny
Maria Figueroa
Eric Solary
Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents
description Chronic myelomonocytic leukaemia is treated with agents that modify DNA methylation but whether they have direct cytotoxic effects is unclear. Here, the authors show that cells from treated patients show marked methylation changes without altered somatic mutation burden, suggesting that cytotoxicity is not a major factor in therapeutic efficacy.
format article
author Jane Merlevede
Nathalie Droin
Tingting Qin
Kristen Meldi
Kenichi Yoshida
Margot Morabito
Emilie Chautard
Didier Auboeuf
Pierre Fenaux
Thorsten Braun
Raphael Itzykson
Stéphane de Botton
Bruno Quesnel
Thérèse Commes
Eric Jourdan
William Vainchenker
Olivier Bernard
Noemie Pata-Merci
Stéphanie Solier
Velimir Gayevskiy
Marcel E. Dinger
Mark J. Cowley
Dorothée Selimoglu-Buet
Vincent Meyer
François Artiguenave
Jean-François Deleuze
Claude Preudhomme
Michael R. Stratton
Ludmil B. Alexandrov
Eric Padron
Seishi Ogawa
Serge Koscielny
Maria Figueroa
Eric Solary
author_facet Jane Merlevede
Nathalie Droin
Tingting Qin
Kristen Meldi
Kenichi Yoshida
Margot Morabito
Emilie Chautard
Didier Auboeuf
Pierre Fenaux
Thorsten Braun
Raphael Itzykson
Stéphane de Botton
Bruno Quesnel
Thérèse Commes
Eric Jourdan
William Vainchenker
Olivier Bernard
Noemie Pata-Merci
Stéphanie Solier
Velimir Gayevskiy
Marcel E. Dinger
Mark J. Cowley
Dorothée Selimoglu-Buet
Vincent Meyer
François Artiguenave
Jean-François Deleuze
Claude Preudhomme
Michael R. Stratton
Ludmil B. Alexandrov
Eric Padron
Seishi Ogawa
Serge Koscielny
Maria Figueroa
Eric Solary
author_sort Jane Merlevede
title Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents
title_short Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents
title_full Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents
title_fullStr Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents
title_full_unstemmed Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents
title_sort mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/3d387d13bd0349019c8a2486e3d50c61
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