Structural basis of RNA polymerase inhibition by viral and host factors

Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design. Here, the authors present the cryo-EM structures of apo Sulfolobus acidocaldarius RNAP and the RNAP complex structures with two regulatory...

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Autores principales:	Simona Pilotto, Thomas Fouqueau, Natalya Lukoyanova, Carol Sheppard, Soizick Lucas-Staat, Luis Miguel Díaz-Santín, Dorota Matelska, David Prangishvili, Alan C. M. Cheung, Finn Werner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d39de805d944392bdd55093bfcb0759
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spelling	oai:doaj.org-article:3d39de805d944392bdd55093bfcb07592021-12-02T18:02:16ZStructural basis of RNA polymerase inhibition by viral and host factors10.1038/s41467-021-25666-52041-1723https://doaj.org/article/3d39de805d944392bdd55093bfcb07592021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25666-5https://doaj.org/toc/2041-1723Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design. Here, the authors present the cryo-EM structures of apo Sulfolobus acidocaldarius RNAP and the RNAP complex structures with two regulatory factors, RIP and TFS4 that inhibit transcription and discuss their inhibitory mechanisms.Simona PilottoThomas FouqueauNatalya LukoyanovaCarol SheppardSoizick Lucas-StaatLuis Miguel Díaz-SantínDorota MatelskaDavid PrangishviliAlan C. M. CheungFinn WernerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simona Pilotto Thomas Fouqueau Natalya Lukoyanova Carol Sheppard Soizick Lucas-Staat Luis Miguel Díaz-Santín Dorota Matelska David Prangishvili Alan C. M. Cheung Finn Werner Structural basis of RNA polymerase inhibition by viral and host factors
description	Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design. Here, the authors present the cryo-EM structures of apo Sulfolobus acidocaldarius RNAP and the RNAP complex structures with two regulatory factors, RIP and TFS4 that inhibit transcription and discuss their inhibitory mechanisms.
format	article
author	Simona Pilotto Thomas Fouqueau Natalya Lukoyanova Carol Sheppard Soizick Lucas-Staat Luis Miguel Díaz-Santín Dorota Matelska David Prangishvili Alan C. M. Cheung Finn Werner
author_facet	Simona Pilotto Thomas Fouqueau Natalya Lukoyanova Carol Sheppard Soizick Lucas-Staat Luis Miguel Díaz-Santín Dorota Matelska David Prangishvili Alan C. M. Cheung Finn Werner
author_sort	Simona Pilotto
title	Structural basis of RNA polymerase inhibition by viral and host factors
title_short	Structural basis of RNA polymerase inhibition by viral and host factors
title_full	Structural basis of RNA polymerase inhibition by viral and host factors
title_fullStr	Structural basis of RNA polymerase inhibition by viral and host factors
title_full_unstemmed	Structural basis of RNA polymerase inhibition by viral and host factors
title_sort	structural basis of rna polymerase inhibition by viral and host factors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d39de805d944392bdd55093bfcb0759
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Structural basis of RNA polymerase inhibition by viral and host factors

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