Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and de...

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Autores principales: Karla Rubio, Indrabahadur Singh, Stephanie Dobersch, Pouya Sarvari, Stefan Günther, Julio Cordero, Aditi Mehta, Lukasz Wujak, Hector Cabrera-Fuentes, Cho-Ming Chao, Peter Braubach, Saverio Bellusci, Werner Seeger, Andreas Günther, Klaus T. Preissner, Malgorzata Wygrecka, Rajkumar Savai, Dulce Papy-Garcia, Gergana Dobreva, Mathias Heikenwalder, Soni Savai-Pullamsetti, Thomas Braun, Guillermo Barreto
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3d39e90c296449c8bbc1d8a1a253f05c
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spelling oai:doaj.org-article:3d39e90c296449c8bbc1d8a1a253f05c2021-12-02T17:02:09ZInactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis10.1038/s41467-019-10066-72041-1723https://doaj.org/article/3d39e90c296449c8bbc1d8a1a253f05c2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10066-7https://doaj.org/toc/2041-1723Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.Karla RubioIndrabahadur SinghStephanie DoberschPouya SarvariStefan GüntherJulio CorderoAditi MehtaLukasz WujakHector Cabrera-FuentesCho-Ming ChaoPeter BraubachSaverio BellusciWerner SeegerAndreas GüntherKlaus T. PreissnerMalgorzata WygreckaRajkumar SavaiDulce Papy-GarciaGergana DobrevaMathias HeikenwalderSoni Savai-PullamsettiThomas BraunGuillermo BarretoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Karla Rubio
Indrabahadur Singh
Stephanie Dobersch
Pouya Sarvari
Stefan Günther
Julio Cordero
Aditi Mehta
Lukasz Wujak
Hector Cabrera-Fuentes
Cho-Ming Chao
Peter Braubach
Saverio Bellusci
Werner Seeger
Andreas Günther
Klaus T. Preissner
Malgorzata Wygrecka
Rajkumar Savai
Dulce Papy-Garcia
Gergana Dobreva
Mathias Heikenwalder
Soni Savai-Pullamsetti
Thomas Braun
Guillermo Barreto
Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
description Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.
format article
author Karla Rubio
Indrabahadur Singh
Stephanie Dobersch
Pouya Sarvari
Stefan Günther
Julio Cordero
Aditi Mehta
Lukasz Wujak
Hector Cabrera-Fuentes
Cho-Ming Chao
Peter Braubach
Saverio Bellusci
Werner Seeger
Andreas Günther
Klaus T. Preissner
Malgorzata Wygrecka
Rajkumar Savai
Dulce Papy-Garcia
Gergana Dobreva
Mathias Heikenwalder
Soni Savai-Pullamsetti
Thomas Braun
Guillermo Barreto
author_facet Karla Rubio
Indrabahadur Singh
Stephanie Dobersch
Pouya Sarvari
Stefan Günther
Julio Cordero
Aditi Mehta
Lukasz Wujak
Hector Cabrera-Fuentes
Cho-Ming Chao
Peter Braubach
Saverio Bellusci
Werner Seeger
Andreas Günther
Klaus T. Preissner
Malgorzata Wygrecka
Rajkumar Savai
Dulce Papy-Garcia
Gergana Dobreva
Mathias Heikenwalder
Soni Savai-Pullamsetti
Thomas Braun
Guillermo Barreto
author_sort Karla Rubio
title Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_short Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_full Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_fullStr Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_full_unstemmed Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_sort inactivation of nuclear histone deacetylases by ep300 disrupts the micee complex in idiopathic pulmonary fibrosis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3d39e90c296449c8bbc1d8a1a253f05c
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