Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes

Background: Our aim was to explore relevance of the proportion between neoplastic cell component and tumor-associated stroma in order to assess its association with confirmed aggressive phenotypes of right/left colon and rectum cancers in a large series of patients. Methods: The quantification of st...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Souza Da Silva Ricella M., Queiroga Eduardo M., de Toledo Osório Cynthia A.B., Cunha Karin S., Dias Eliane P.
Formato:	article
Lenguaje:	EN
Publicado:	Institute of Oncology, Sremska Kamenica, Serbia 2022
Materias:	tumor microenvironment tumor-stroma proportion colorectal cancer advanced disease aggressive phenotype Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3d3a8b74cbbe4ddb9e042b2516e0f1b4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3d3a8b74cbbe4ddb9e042b2516e0f1b4
record_format	dspace
spelling	oai:doaj.org-article:3d3a8b74cbbe4ddb9e042b2516e0f1b42021-12-05T18:01:24ZStromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes0354-73101450-952010.2298/AOO210403003Shttps://doaj.org/article/3d3a8b74cbbe4ddb9e042b2516e0f1b42022-01-01T00:00:00Zhttps://scindeks-clanci.ceon.rs/data/pdf/0354-7310/2022/0354-73102201001S.pdfhttps://doaj.org/toc/0354-7310https://doaj.org/toc/1450-9520Background: Our aim was to explore relevance of the proportion between neoplastic cell component and tumor-associated stroma in order to assess its association with confirmed aggressive phenotypes of right/left colon and rectum cancers in a large series of patients. Methods: The quantification of stroma component was performed in patients diagnosed with colorectal adenocarcinoma who underwent surgical resection. The analyzed variables were age, gender, anatomical/pathological features, and tumor-stroma proportion. Tumor-stroma proportion was estimated based on slides used in routine pathology for determination of T status and was described as low, with a stromal percentage ≤50% or high, with a stromal percentage >50%. The tumor-stroma proportion was estimated by two observers, and the inter-observer agreement was assessed. Results: The sample included 390 colorectal adenocarcinoma patients. Stroma-rich tumors were observed in 53.3% of cases. Well-differentiated tumors had the lowest stromal proportions (p = 0.028). Stroma-poor tumors showed less depth of invasion (p<0.001). High stromal content was observed in association with tumor budding, perineural, angiolymphatic, and lymph node involvement, and distant metastasis (p≤0.001). Colorectal adenocarcinoma without lymph node or distant metastasis involvement had lower stromal proportion, while metastatic ones exhibited high stromal content (p <0.001). The inter-rater reliability (concordance) between the estimations of pathologists for tumor-stroma proportions was high (c=0.746). Conclusion: The tumor-stroma proportion in colorectal adenocarcinoma was associated with adverse prognostic factors, reflecting the stage of the disease. Stroma-rich tumors showed a significant correlation with advancement of the disease and its aggressiveness. Due to its availability tumor-stroma proportion evaluation has high application potential and can complement current staging system for colorectal adenocarcinoma.Souza Da Silva Ricella M.Queiroga Eduardo M.de Toledo Osório Cynthia A.B.Cunha Karin S.Dias Eliane P.Institute of Oncology, Sremska Kamenica, Serbiaarticletumor microenvironmenttumor-stroma proportioncolorectal canceradvanced diseaseaggressive phenotypeNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENArchive of Oncology, Vol 28, Iss 1, Pp 1-6 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor microenvironment tumor-stroma proportion colorectal cancer advanced disease aggressive phenotype Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	tumor microenvironment tumor-stroma proportion colorectal cancer advanced disease aggressive phenotype Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Souza Da Silva Ricella M. Queiroga Eduardo M. de Toledo Osório Cynthia A.B. Cunha Karin S. Dias Eliane P. Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes
description	Background: Our aim was to explore relevance of the proportion between neoplastic cell component and tumor-associated stroma in order to assess its association with confirmed aggressive phenotypes of right/left colon and rectum cancers in a large series of patients. Methods: The quantification of stroma component was performed in patients diagnosed with colorectal adenocarcinoma who underwent surgical resection. The analyzed variables were age, gender, anatomical/pathological features, and tumor-stroma proportion. Tumor-stroma proportion was estimated based on slides used in routine pathology for determination of T status and was described as low, with a stromal percentage ≤50% or high, with a stromal percentage >50%. The tumor-stroma proportion was estimated by two observers, and the inter-observer agreement was assessed. Results: The sample included 390 colorectal adenocarcinoma patients. Stroma-rich tumors were observed in 53.3% of cases. Well-differentiated tumors had the lowest stromal proportions (p = 0.028). Stroma-poor tumors showed less depth of invasion (p<0.001). High stromal content was observed in association with tumor budding, perineural, angiolymphatic, and lymph node involvement, and distant metastasis (p≤0.001). Colorectal adenocarcinoma without lymph node or distant metastasis involvement had lower stromal proportion, while metastatic ones exhibited high stromal content (p <0.001). The inter-rater reliability (concordance) between the estimations of pathologists for tumor-stroma proportions was high (c=0.746). Conclusion: The tumor-stroma proportion in colorectal adenocarcinoma was associated with adverse prognostic factors, reflecting the stage of the disease. Stroma-rich tumors showed a significant correlation with advancement of the disease and its aggressiveness. Due to its availability tumor-stroma proportion evaluation has high application potential and can complement current staging system for colorectal adenocarcinoma.
format	article
author	Souza Da Silva Ricella M. Queiroga Eduardo M. de Toledo Osório Cynthia A.B. Cunha Karin S. Dias Eliane P.
author_facet	Souza Da Silva Ricella M. Queiroga Eduardo M. de Toledo Osório Cynthia A.B. Cunha Karin S. Dias Eliane P.
author_sort	Souza Da Silva Ricella M.
title	Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes
title_short	Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes
title_full	Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes
title_fullStr	Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes
title_full_unstemmed	Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes
title_sort	stromal scoring in advanced colon and rectal cancer: stroma-rich tumors and their association with aggressive phenotypes
publisher	Institute of Oncology, Sremska Kamenica, Serbia
publishDate	2022
url	https://doaj.org/article/3d3a8b74cbbe4ddb9e042b2516e0f1b4
work_keys_str_mv	AT souzadasilvaricellam stromalscoringinadvancedcolonandrectalcancerstromarichtumorsandtheirassociationwithaggressivephenotypes AT queirogaeduardom stromalscoringinadvancedcolonandrectalcancerstromarichtumorsandtheirassociationwithaggressivephenotypes AT detoledoosoriocynthiaab stromalscoringinadvancedcolonandrectalcancerstromarichtumorsandtheirassociationwithaggressivephenotypes AT cunhakarins stromalscoringinadvancedcolonandrectalcancerstromarichtumorsandtheirassociationwithaggressivephenotypes AT diaselianep stromalscoringinadvancedcolonandrectalcancerstromarichtumorsandtheirassociationwithaggressivephenotypes
_version_	1718371232543408128

Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes

Ejemplares similares